Organism | UniProt | Comment | Textmining |
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Rattus norvegicus | - |
- |
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Source Tissue | Comment | Organism | Textmining |
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myometrium | during gestation, isoforms Sphk1 and Sphk2 are co-expressed. The levels and activity of SphK1/2 are modest at midgestation , increase at day 19 and progressively decline to low at postpartum. Inhibition of protein kinase C and ERK reduces SphK1/2 activity. In primary cultures of myometrial cells from day 19 pregnant rats, induction of COX2 is mediated by 4-phorbol 12,13-dibutyrate and IL-1 through sequential activation of protein kinase C, ERK1/2, and SphK1. Sphingosine 1-phosphate produced by SphK1 is released in the medium. In day 12 myometrial tissues, the release of sphingosine 1-phosphate is markedly reduced in association with low levels of SphK1 and COX2 | Rattus norvegicus | - |