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Literature summary for 2.7.1.91 extracted from
- Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner (2008), Biol. Chem., 389, 1399-1407.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| mesangial cell | renal mesangial cell | Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | wild-type mesangial cells respond to staurosporine with increased DNA fragmentation and caspase-3 processing, which is enhanced in SK1-/- cells. SK2-/- cells are highly resistant to staurosporine-induced apoptosis. The basal phosphorylation and activity of the anti-apoptotic protein kinase B and of its substrate Bad are decreased in SK1-/- but not in SK2-/- cells. Upon staurosporine treatment, phosphorylation of protein kinase B and Bad decrease in wild-type and SK1-/- cells, but remain high in SK2-/- cells. The anti-apoptotic Bcl-XL is significantly upregulated in SK2-/- cells | Mus musculus |
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Release 2023.1 (January 2023)
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