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Literature summary for 2.7.1.91 extracted from

  • Gamble, J.R.; Sun, W.Y.; Li, X.; Hahn, C.N.; Pitson, S.M.; Vadas, M.A.; Bonder, C.S.
    Sphingosine kinase-1 associates with integrin alphaVbeta3 to mediate endothelial cell survival (2009), Am. J. Pathol., 175, 2217-2225.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function under basal conditions, SK1, integrin alphaVbeta3 and CD31 exist as a heterotrimeric complex. Under conditions that affect endothelial cell survival such as loss of contact with the extracellular matrix or growth factor activation, more of this heterotrimeric complex forms. Increased heterotrimeric complex formation requires SK1 phosphorylation at serine 225 for, activation of integrin alphaVbeta3, and endothelial cell survival signals, including Bcl-X and nuclear factor-B pathways. beta3-Integrin depletion confirms the requirement for this heterotrimeric complex in SK1-mediated endothelial cell survival Homo sapiens