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Literature summary for 2.7.1.91 extracted from

  • Taha, T.A.; El-Alwani, M.; Hannun, Y.A.; Obeid, L.M.
    Sphingosine kinase-1 is cleaved by cathepsin B in vitro: Identification of the initial cleavage sites for the protease (2006), FEBS Lett., 580, 6047-6054.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
H121E reduced activity by 20% Homo sapiens
H122A the mutation reduces cleavage by cathepsin B at the mutation site, reduced activity by 60% Homo sapiens
H122Y no detectable difference in activity compared to the wild type enzyme Rattus norvegicus
N121E the mutation reduces cleavage by cathepsin B at the mutation site, reduced activity by 20% Homo sapiens
Y123A reduced activity by 40% Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NYA1
-
-
Mus musculus Q8CI15
-
-
Rattus norvegicus Q91V26
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
Homo sapiens ADP + sphingosine 1-phosphate
-
?
ATP + sphingosine
-
Mus musculus ADP + sphingosine 1-phosphate
-
?
ATP + sphingosine
-
Rattus norvegicus ADP + sphingosine 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
SK1
-
Homo sapiens
SK1
-
Mus musculus
SK1
-
Rattus norvegicus
sphingosine kinase-1 is a substrate for the cysteine protease cathepsin B Homo sapiens
sphingosine kinase-1 is a substrate for the cysteine protease cathepsin B Mus musculus
sphingosine kinase-1 is a substrate for the cysteine protease cathepsin B Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Mus musculus
ATP
-
Rattus norvegicus