Protein Variants | Comment | Organism |
---|---|---|
H121E | reduced activity by 20% | Homo sapiens |
H122A | the mutation reduces cleavage by cathepsin B at the mutation site, reduced activity by 60% | Homo sapiens |
H122Y | no detectable difference in activity compared to the wild type enzyme | Rattus norvegicus |
N121E | the mutation reduces cleavage by cathepsin B at the mutation site, reduced activity by 20% | Homo sapiens |
Y123A | reduced activity by 40% | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NYA1 | - |
- |
Mus musculus | Q8CI15 | - |
- |
Rattus norvegicus | Q91V26 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
? | |
ATP + sphingosine | - |
Mus musculus | ADP + sphingosine 1-phosphate | - |
? | |
ATP + sphingosine | - |
Rattus norvegicus | ADP + sphingosine 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SK1 | - |
Homo sapiens |
SK1 | - |
Mus musculus |
SK1 | - |
Rattus norvegicus |
sphingosine kinase-1 | is a substrate for the cysteine protease cathepsin B | Homo sapiens |
sphingosine kinase-1 | is a substrate for the cysteine protease cathepsin B | Mus musculus |
sphingosine kinase-1 | is a substrate for the cysteine protease cathepsin B | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Mus musculus | |
ATP | - |
Rattus norvegicus |