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Literature summary for 2.7.1.91 extracted from
- Sphingosine kinase signalling in immune cells (2005), Clin. Exp. Pharmacol. Physiol., 32, 153-161.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Drosophila melanogaster |
- |
Saccharomyces cerevisiae |
- |
Tetrahymena pyriformis |
- |
Arabidopsis thaliana |
- |
Caenorhabditis elegans |
| DNA and amino acid sequence determination and analysis | Mus musculus |
| DNA and amino acid sequence determination and analysis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DL-threo-dihydrosphingosine | - |
Homo sapiens |  |
| DL-threo-dihydrosphingosine | - |
Mus musculus | |
| N,N-dimethylsphingosine | - |
Homo sapiens | |
| N,N-dimethylsphingosine | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| extracellular | - |
Mus musculus | - |
- |
| extracellular | - |
Homo sapiens | - |
- |
| additional information | subcellular localization depends on the tissue type | Mus musculus | - |
- |
| additional information | subcellular localization depends on the tissue type | Homo sapiens | - |
- |
| nucleus | - |
Mus musculus | 5634 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
| plasma membrane | - |
Mus musculus | 5886 | - |
| plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-erythro-sphingosine | Mus musculus | - |
ADP + D-erythro-sphingosine 1-phosphate | - |
ir | |
| ATP + D-erythro-sphingosine | Homo sapiens | - |
ADP + D-erythro-sphingosine 1-phosphate | - |
ir | |
| ATP + phytosphingosine | Mus musculus | - |
ADP + phytosphingosine 1-phosphate | - |
ir | |
| ATP + phytosphingosine | Homo sapiens | - |
ADP + phytosphingosine 1-phosphate | - |
ir | |
| ATP + sphinganine | Mus musculus | - |
ADP + sphinganine 1-phosphate | - |
? | |
| ATP + sphinganine | Homo sapiens | - |
ADP + sphinganine 1-phosphate | - |
? | |
| ATP + sphingosine | Drosophila melanogaster | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | Mus musculus | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | Homo sapiens | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | Saccharomyces cerevisiae | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | Tetrahymena pyriformis | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | Arabidopsis thaliana | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | Caenorhabditis elegans | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| additional information | Homo sapiens | the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation and via neutrophil, macrophage, and monocyte activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis, chemotaxis of leukocytes | ? | - |
? | |
| additional information | Mus musculus | the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Caenorhabditis elegans | - |
- |
- |
| Drosophila melanogaster | - |
- |
- |
| Homo sapiens | - |
2 isozymes SPHK1 and SPHK2 | - |
| Mus musculus | - |
2 isozymes SPHK1 and SPHK2 | - |
| Saccharomyces cerevisiae | - |
- |
- |
| Tetrahymena pyriformis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| isozyme SPHK1 | Mus musculus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism | Drosophila melanogaster | |
| ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism | Saccharomyces cerevisiae | |
| ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism | Tetrahymena pyriformis | |
| ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism | Arabidopsis thaliana | |
| ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism | Caenorhabditis elegans | |
| ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism, the catalytic domain contains the C1-C5 sequence stretches and the ATP-binding site | Mus musculus | |
| ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism, the catalytic domain contains the C1-C5 sequence stretches and the ATP-binding site | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Mus musculus | - |
| blood platelet | - |
Homo sapiens | - |
| brain | white matter, cerebellum, cerebrum, red nucleus, cerebral peduncle | Mus musculus | - |
| brain | white matter, cerebellum, cerebrum, red nucleus, cerebral peduncle | Homo sapiens | - |
| cerebellum | - |
Mus musculus | - |
| cerebellum | - |
Homo sapiens | - |
| cerebrum | - |
Mus musculus | - |
| cerebrum | - |
Homo sapiens | - |
| endothelium | - |
Mus musculus | - |
| endothelium | - |
Homo sapiens | - |
| heart | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| leukocyte | of peripheral blood | Mus musculus | - |
| leukocyte | of peripheral blood | Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Mus musculus | - |
| lung | - |
Homo sapiens | - |
| megacaryocyte | - |
Homo sapiens | - |
| megakaryocyte | - |
Mus musculus | - |
| additional information | isozyme tissue distribution | Mus musculus | - |
| additional information | isozyme tissue distribution | Homo sapiens | - |
| neutrophil | - |
Homo sapiens | - |
| spleen | - |
Mus musculus | - |
| spleen | - |
Homo sapiens | - |
| thymus | - |
Mus musculus | - |
| thymus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-erythro-sphingosine | - |
Mus musculus | ADP + D-erythro-sphingosine 1-phosphate | - |
ir | |
| ATP + D-erythro-sphingosine | - |
Homo sapiens | ADP + D-erythro-sphingosine 1-phosphate | - |
ir | |
| ATP + phytosphingosine | - |
Mus musculus | ADP + phytosphingosine 1-phosphate | - |
ir | |
| ATP + phytosphingosine | - |
Homo sapiens | ADP + phytosphingosine 1-phosphate | - |
ir | |
| ATP + sphinganine | - |
Mus musculus | ADP + sphinganine 1-phosphate | - |
? | |
| ATP + sphinganine | - |
Homo sapiens | ADP + sphinganine 1-phosphate | - |
? | |
| ATP + sphingosine | - |
Drosophila melanogaster | ADP + sphingosine 1-phosphate | - |
ir | |
| ATP + sphingosine | - |
Mus musculus | ADP + sphingosine 1-phosphate | - |
ir | |
| ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
ir | |
| ATP + sphingosine | - |
Saccharomyces cerevisiae | ADP + sphingosine 1-phosphate | - |
ir | |
| ATP + sphingosine | - |
Tetrahymena pyriformis | ADP + sphingosine 1-phosphate | - |
ir | |
| ATP + sphingosine | - |
Arabidopsis thaliana | ADP + sphingosine 1-phosphate | - |
ir | |
| ATP + sphingosine | - |
Caenorhabditis elegans | ADP + sphingosine 1-phosphate | - |
ir | |
| ATP + sphingosine | - |
Drosophila melanogaster | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | - |
Mus musculus | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | - |
Saccharomyces cerevisiae | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | - |
Tetrahymena pyriformis | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | - |
Arabidopsis thaliana | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| ATP + sphingosine | - |
Caenorhabditis elegans | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
| additional information | the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation and via neutrophil, macrophage, and monocyte activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis, chemotaxis of leukocytes | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sphinganine kinase | - |
Drosophila melanogaster |
| sphinganine kinase | - |
Mus musculus |
| sphinganine kinase | - |
Homo sapiens |
| sphinganine kinase | - |
Saccharomyces cerevisiae |
| sphinganine kinase | - |
Tetrahymena pyriformis |
| sphinganine kinase | - |
Arabidopsis thaliana |
| sphinganine kinase | - |
Caenorhabditis elegans |
| SPHK | - |
Drosophila melanogaster |
| SPHK | - |
Mus musculus |
| SPHK | - |
Homo sapiens |
| SPHK | - |
Saccharomyces cerevisiae |
| SPHK | - |
Tetrahymena pyriformis |
| SPHK | - |
Arabidopsis thaliana |
| SPHK | - |
Caenorhabditis elegans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Drosophila melanogaster | |
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Saccharomyces cerevisiae | |
| ATP | - |
Tetrahymena pyriformis | |
| ATP | - |
Arabidopsis thaliana | |
| ATP | - |
Caenorhabditis elegans | |
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Release 2023.1 (January 2023)
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