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Literature summary for 2.7.1.91 extracted from

  • Liu, H.; Sugiura, M.; Nava, V.E.; Edsall, L.C.; Kono, K.; Poulton, S.; Milstien, S.; Kohama, T.; Spiegel, S.
    Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform (2000), J. Biol. Chem., 275, 19513-19520.
    View publication on PubMed
Search for more literature for 2.7.1.91

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens
-
 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
KCl IC50 200 mM Mus musculus
N,N-dimethylsphingosine
-
 Homo sapiens
N,N-dimethylsphingosine
-
 Mus musculus
NaCl IC50 200 mM Mus musculus
Triton X-100 above 0.005% Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
 D-(+)-erythro-sphinganine
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NRA0 SPHK2
-
Mus musculus Q9JIA7 SPHK2
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information tissue distribution Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-(+)-erythro-sphinganine
-
 Mus musculus ADP + D-(+)-erythro-sphinganine 1-phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.012
-
 N,N-dimethylsphingosine
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
200
-
 IC50 200 mM Mus musculus NaCl
200
-
 IC50 200 mM Mus musculus KCl