Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-fructose 1,6-bisphosphate | forward reaction, product inhibition, kinetics | Giardia intestinalis | |
D-fructose 2,6-bisphosphate | - |
Giardia intestinalis | |
D-fructose 6-phosphate | reverse reaction, product inhibition, kinetics | Giardia intestinalis | |
diphosphate | kinetics; reverse reaction | Giardia intestinalis | |
phosphate | forward reaction, product inhibition, kinetics | Giardia intestinalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Giardia intestinalis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Giardia intestinalis | |
Mg2+ | substrates are Mg2+-chelated complexes of phosphate and diphosphate, respectively, not uncomplexed ligands | Giardia intestinalis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Giardia intestinalis | - |
- |
- |
Giardia intestinalis Portland-1 / ATCC 30888 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Giardia intestinalis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diphosphate + D-fructose 6-phosphate | substrates are Mg2+-chelated complexes of phosphate and diphosphate, respectively, not uncomplexed ligands | Giardia intestinalis | phosphate + D-fructose 1,6-bisphosphate | - |
r | |
diphosphate + D-fructose 6-phosphate | specific for diphosphate as phosphor donor | Giardia intestinalis | phosphate + D-fructose 1,6-bisphosphate | - |
r | |
diphosphate + D-fructose 6-phosphate | substrates are Mg2+-chelated complexes of phosphate and diphosphate, respectively, not uncomplexed ligands | Giardia intestinalis Portland-1 / ATCC 30888 | phosphate + D-fructose 1,6-bisphosphate | - |
r | |
diphosphate + D-fructose 6-phosphate | specific for diphosphate as phosphor donor | Giardia intestinalis Portland-1 / ATCC 30888 | phosphate + D-fructose 1,6-bisphosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
PPi-dependent phosphofructokinase | - |
Giardia intestinalis |
PPi-PFK | - |
Giardia intestinalis |
pyrophosphate-dependent phosphofructokinase | - |
Giardia intestinalis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
83 | - |
phosphate | both reaction directions | Giardia intestinalis | |
83 | - |
phosphate | substrate is a Mg2+-chelated complexe of phosphate, not uncomplexed ligand | Giardia intestinalis | |
83 | - |
phosphate | pH 7.4, 30°C | Giardia intestinalis | |
83 | - |
diphosphate | both reaction directions, pH 7.4, 30°C | Giardia intestinalis | |
83 | - |
diphosphate | substrate is a Mg2+-chelated complexe of diphosphate, not uncomplexed ligand | Giardia intestinalis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic product inhibition | Giardia intestinalis | |
3.24 | - |
D-fructose 2,6-bisphosphate | versus fructose 1,6-bisphosphate, competitive, pH 7.4, 30°C | Giardia intestinalis | |
7.36 | - |
D-fructose 2,6-bisphosphate | versus phosphate, pH 7.4, 30°C | Giardia intestinalis |