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Literature summary for 2.7.1.81 extracted from

  • Hiles, R.A.; Henderson, LaVell M.
    The partial purification and properties of hydroxylysine kinase from rat liver (1972), J. Biol. Chem., 247, 646-651.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-Amino-5-hydroxyadipate 4 isomers, 40 mM, strong inhibition Rattus norvegicus
4,5-Dehydro-(trans)-L-lysine
-
Rattus norvegicus
carnitine 2 isomers Rattus norvegicus
choline 40 mM, weak inhibition Rattus norvegicus
D-Lysine
-
Rattus norvegicus
D-ornithine
-
Rattus norvegicus
ethanolamine 40 mM, weak inhibition Rattus norvegicus
Hydroxy-L-pipecolate
-
Rattus norvegicus
hydroxy-L-proline 40 mM, strong Rattus norvegicus
L-2,4-diamino-n-butyrate
-
Rattus norvegicus
L-homoserine 40 mM, weak inhibition Rattus norvegicus
L-lysine higher inhibitory effect than with D-lysine Rattus norvegicus
L-ornithine higher inhibitory effect than with D-ornithine Rattus norvegicus
Mn2+ at 1 mM, in presence of 1 mM Mg2+, strong inhibition, but activation in absence of Mg2+ Rattus norvegicus
S-aminoethyl-L-cysteine
-
Rattus norvegicus
Zn2+ at 1 mM, in presence of 1 mM Mg2+, strong inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0056
-
hydroxy-L-lysine pH 8.0, 37°C Rattus norvegicus
0.0062
-
allohydroxy-L-lysine pH 8.0, 37°C Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+ Rattus norvegicus
Co2+ requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+ Rattus norvegicus
Cu2+ requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+ Rattus norvegicus
Fe2+ requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+ Rattus norvegicus
Hg2+ requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+ Rattus norvegicus
Mg2+ requirement of a divalent metal ion, Mg2+ yields highest activity Rattus norvegicus
Mn2+ requirement of a divalent metal ion, 1 mM, 13% of activity compared to Mg2+, strong inhibition in presence of 1 mM Mg2+ Rattus norvegicus
additional information K+, Li+ have no influence Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + 5-hydroxy-L-lysine Rattus norvegicus erythro-5-hydroxy-L8-lysine GDP + O-phosphohydroxy-L-lysine
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Cebus albifrons
-
-
-
Chlorocebus aethiops
-
-
-
Gallus gallus
-
-
-
Mus musculus
-
-
-
no activity in Homo sapiens
-
no activity in liver and kidney
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
1200fold Rattus norvegicus
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-
kidney
-
Rattus norvegicus
-
kidney
-
Oryctolagus cuniculus
-
kidney
-
Chlorocebus aethiops
-
kidney
-
Cebus albifrons
-
liver
-
Gallus gallus
-
liver
-
Mus musculus
-
liver
-
Rattus norvegicus
-
liver
-
Bos taurus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Cebus albifrons
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.114
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
frozen, little loss of activity for weeks Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + 5-hydroxy-L-lysine erythro-5-hydroxy-L8-lysine Rattus norvegicus GDP + O-phosphohydroxy-L-lysine
-
?
GTP + allohydroxy-L-lysine
-
Rattus norvegicus ?
-
?
additional information no activity with D-isomers, ITP can partially substitute for GTP Rattus norvegicus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6 9 25% of maximal activity at pH 6.0, 35% of maximal activity at pH 9.0 Rattus norvegicus