Literature summary for 2.7.1.78 extracted from

Ma, C.; Fang, H.; Wang, K.; Xia, K.; Chen, H.; He, H.; Zeng, W.
Simultaneous detection of kinase and phosphatase activities of polynucleotide kinase using molecular beacon probes (2013), Anal. Biochem., 443, 166-168.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 5'-dephospho-DNA	Tequatrovirus T4	-	ADP + 5'-phospho-DNA	-	?
additional information	Tequatrovirus T4	the enzyme catalyzes the phosphorylation of the 5'-hydroxyl terminus and the dephosphorylation of the 3'-phosphate terminus of DNA	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 5'-dephospho-DNA	-	Tequatrovirus T4	ADP + 5'-phospho-DNA	-	?
additional information	the enzyme catalyzes the phosphorylation of the 5'-hydroxyl terminus and the dephosphorylation of the 3'-phosphate terminus of DNA	Tequatrovirus T4	?	-	?

Synonyms

Synonyms	Comment	Organism
PNK	-	Tequatrovirus T4
polynucleotide kinase	-	Tequatrovirus T4

General Information

General Information	Comment	Organism
physiological function	posphorylation and dephosphorylation of DNA by polynucleotide kinase has an important role in DNA damage repair, replication, and recombination	Tequatrovirus T4

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Release 2023.1 (January 2023)