Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5'-dephospho-RNA | Tequatrovirus T4 | - |
ADP + 5'-phospho-RNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Tequatrovirus T4 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5'-dephospho-RNA | - |
Tequatrovirus T4 | ADP + 5'-phospho-RNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PNK | - |
Tequatrovirus T4 |
T4 PNK | - |
Tequatrovirus T4 |
T4 polynucleotide kinase/phosphatase | - |
Tequatrovirus T4 |
General Information | Comment | Organism |
---|---|---|
physiological function | degradation of RegB-cleaved mRNAs depends on a functional T4 polynucleotide kinase/phosphatase. PNK controls the decay of early transcripts predominantly from their 5'-termini. The 5'-OH produced by RegB cleavage is phosphorylated by the kinase activity of PNK. When the 5'-OH RNA end generated by RegB is not phosphorylated by PNK, the attack by RNases E and G is blocked or decreased over a distance of about 300 nt from the RegB site. But after PNK has modified the 5'-terminus and RNase G (or E) has cut at secondary sites, the new 5'-monophosphorylated RNA ends can presumably activate RNases E and G in cascade. The PNK-dependent pathway of degradation becomes effective 5 min postinfectio. The T4 PNK also has a role during normal phage development | Tequatrovirus T4 |