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Literature summary for 2.7.1.78 extracted from

  • Dobson, C.J.; Allinson, S.L.
    The phosphatase activity of mammalian polynucleotide kinase takes precedence over its kinase activity in repair of single strand breaks (2006), Nucleic Acids Res., 34, 2230-2237.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta2(DE3)pLysS cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D171A complete loss of activity Homo sapiens
D173A complete loss of activity Homo sapiens
K378A complete loss of activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5'-dephospho-DNA
-
Homo sapiens ADP + 5'-phospho-DNA
-
?

Synonyms

Synonyms Comment Organism
PNK
-
Homo sapiens
polynucleotide kinase the phosphatase activity of the purified enzyme is significantly more active than its kinase activity Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens