Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.78 extracted from

  • Karimi-Busheri, F.; Weinfeld, M.
    Purification and substrate specificity of polydeoxyribonucleotide kinases isolated from calf thymus and rat liver (1997), J. Cell. Biochem., 64, 258-272.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Rattus norvegicus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus
Mg2+
-
Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
x * 60000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5'-dephospho-DNA Rattus norvegicus
-
ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA Bos taurus involved in repair of DNA single strand breaks ADP + 5'-phospho-DNA
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
calf
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
10860fold, to near homogeneity Rattus norvegicus
6717fold, to near homogeneity Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
liver
-
Bos taurus
-
thymus
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0012
-
purified enzyme Bos taurus
0.0028
-
purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5'-dephospho-DNA
-
Rattus norvegicus ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA minimal length of the substrate is 7-8 nucleotides, optimal size is more than 18 nucleotides in length Rattus norvegicus ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA minimal length of the substrate is 7-8 nucleotides, optimal size is more than 18 nucleotides in length Bos taurus ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA no preference for overhanging 5'-ends Bos taurus ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA single stranded DNA Rattus norvegicus ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA single stranded DNA Bos taurus ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA specific for DNA Rattus norvegicus ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA specific for DNA Bos taurus ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA micrococcal-nuclease-treated calf thymus DNA Bos taurus ADP + 5'-phospho-DNA
-
?
ATP + 5'-dephospho-DNA involved in repair of DNA single strand breaks Bos taurus ADP + 5'-phospho-DNA
-
?
ATP + synthetic oligonucleotide
-
Rattus norvegicus ADP + oligonucleotide 5'-phosphate
-
?
ATP + synthetic oligonucleotide low activity with homopolymers such as oligo(dA)24 and oligo(dT)24 Bos taurus ADP + oligonucleotide 5'-phosphate
-
?
additional information substrate specificity Bos taurus ?
-
?
additional information enzyme also has DNA 3'-phosphatase activity Rattus norvegicus ?
-
?
additional information enzyme also has DNA 3'-phosphatase activity Bos taurus ?
-
?

Subunits

Subunits Comment Organism
? x * 60000, SDS-PAGE Rattus norvegicus
? x * 61000-62000, SDS-PAGE Bos taurus

Synonyms

Synonyms Comment Organism
More enzyme also possesses a 3'-phosphatase activity Rattus norvegicus
More enzyme also possesses a 3'-phosphatase activity Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus
37
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
assay at Rattus norvegicus
5.5
-
assay at Bos taurus
6
-
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Rattus norvegicus
ATP dependent on Bos taurus

pI Value

Organism Comment pI Value Maximum pI Value
Bos taurus
-
-
8.5