Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | inhibition above 1 mM | Mus musculus | |
NH4+ | weak inhibition | Mus musculus | |
sulfate | weak | Mus musculus | |
Zn2+ | inhibition in presence of Mg2+ | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0036 | - |
5'-hydroxyl poly(A) | pH 8.4, 37°C | Mus musculus | |
0.22 | - |
[gamma-S]ATP | pH 8.4, 37°C | Mus musculus | |
0.53 | - |
[gamma-S]GTP | pH 8.4, 37°C | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | about 17% of the activity with Mg2+, synergistic to Mg2+ | Mus musculus | |
Mg2+ | required | Mus musculus | |
Mn2+ | no activation, 50% inhibition at 1 mM | Mus musculus | |
NH4+ | slightly inhibitory | Mus musculus | |
Zn2+ | no activation, inhibition in presence of Mg2+ | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
93000 | - |
1 * 93000, SDS-PAGE | Mus musculus |
96000 | - |
gel filtration, native PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial, 35fold | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell suspension culture | L-cells | Mus musculus | - |
L-cell | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0007 | - |
partially purified enzyme, substrate RNA | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5'-dephospho-DNA | low activity | Mus musculus | ADP + 5'-phospho-DNA | - |
? | |
ATP + 5'-dephospho-DNA | micrococcal-nuclease-treated calf thymus DNA is not effectively phosphorylated | Mus musculus | ADP + 5'-phospho-DNA | - |
? | |
ATP + 5'-dephospho-RNA | much more efficient as substrate than DNA | Mus musculus | ADP + 5'-phospho-RNA | - |
? | |
ATP + 5'-hydroxyl poly(A) | - |
Mus musculus | ? | - |
? | |
ATP + synthetic oligonucleotide | 5'-hydroxyl poly(A) | Mus musculus | ADP + oligonucleotide 5'-phosphate | - |
? | |
[gamma-S]ATP + 5'-dephospho-RNA | - |
Mus musculus | [gamma-S]ADP + 5'-phospho-RNA | - |
? | |
[gamma-S]GTP + 5'-dephospho-RNA | - |
Mus musculus | [gamma-S]GDP + 5'-phospho-RNA | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 93000, SDS-PAGE | Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
substrate DNA | Mus musculus |
9 | - |
substrate RNA | Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 9.4 | pH 7.5: about 50% of activity maximum, pH 8.4 and pH 9.4: about 85% of activity maximum | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[2-(1H-imidazol-4-yl)ethyl]piperazine-1,2-dicarboxamide | - |
Mus musculus | |
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[3-(1H-imidazol-4-yl)propyl]piperazine-1,2-dicarboxamide | - |
Mus musculus | |
ATP | - |
Mus musculus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Mus musculus | - |
- |
4.8 |