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Literature summary for 2.7.1.76 extracted from

  • Krygier, V.; Momparler, R.L.
    Mammalian deoxynucleoside kinases. II. Deoxyadenosine kinase: purification and properties (1971), J. Biol. Chem., 246, 2745-2751.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Hg2+ 0.01 mM, 25% inhibition, 0.1 mM, almost complete inhibition Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activation, can replace Mg2+ Bos taurus
Mg2+ required for activity Bos taurus
Mn2+ activation, can replace Mg2+ Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63000
-
gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
streptomycin sulfate, protamine sulfate, ammonium sulfate, Sephadex G-150 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.073
-
-
Bos taurus

Storage Stability

Storage Stability Organism
-20°C, 60% glycerol, at least 3 months, slight loss of activity Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cytidine approx. 18% of activity with deoxyadenosine Bos taurus ADP + CMP
-
?
ATP + deoxyadenosine
-
Bos taurus ADP + dAMP
-
?
ATP + deoxycytidine approx. 12% of activity with deoxyadenosine Bos taurus ADP + dCMP
-
?
ATP + deoxyguanosine
-
Bos taurus ADP + dGMP
-
?
dTTP + deoxyadenosine 75% of activity with ATP Bos taurus dTDP + dAMP
-
?
GTP + deoxyadenosine
-
Bos taurus GDP + dAMP
-
?
UTP + deoxyadenosine 90% of activity with ATP Bos taurus UDP + dAMP
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
broad optimum, 10% difference in activity between pH 6.5 and pH 8.5 Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
5.7 8.8 approx. half-maximal activity at pH 5.7, approx. 80% of maximal activity at pH 8.8 Bos taurus