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Literature summary for 2.7.1.74 extracted from

  • Zhong, R.; Xin, R.; Chen, Z.; Liang, N.; Liu, Y.; Ma, S.; Liu, X.
    The role of deoxycytidine kinase (dCK) in radiation-induced cell death (2016), Int. J. Mol. Sci., 17, 1939 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.74

Protein Variants

Protein Variants Comment Organism
S74A the mutation abrogates phosphorylation of the protein. The ratio of phospho-Akt/Akt, phospho-mTOR/mTOR, phospho-P70S6K/P70S6K does not significantly decrease in mutant cells following ionizing radiation treatment Homo sapiens
S74E the mutation mimics phosphorylation of the protein. The ratio of phospho-Akt/Akt, phospho-mTOR/mTOR, phospho-P70S6K/P70S6K significantly decreases in mutant cells following ionizing radiation treatment Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NTP + deoxycytidine Homo sapiens
-
 NDP + dCMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P27707
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is phosphorylated on serine 74 by the ataxia-telangiectasia mutated kinase Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the phosphorylated and activated enzyme can inhibit ionizing radiation-induced cell death including apoptosis and mitotic catastrophe, and promote ionizing radiation-induced autophagy through PI3K/Akt/mTOR pathway. The enzyme is required for the G2/M cell cycle checkpoint and to protect cells against mitotic catastrophe Homo sapiens