Protein Variants | Comment | Organism |
---|---|---|
S74A | the mutation abrogates phosphorylation of the protein. The ratio of phospho-Akt/Akt, phospho-mTOR/mTOR, phospho-P70S6K/P70S6K does not significantly decrease in mutant cells following ionizing radiation treatment | Homo sapiens |
S74E | the mutation mimics phosphorylation of the protein. The ratio of phospho-Akt/Akt, phospho-mTOR/mTOR, phospho-P70S6K/P70S6K significantly decreases in mutant cells following ionizing radiation treatment | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NTP + deoxycytidine | Homo sapiens | - |
NDP + dCMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27707 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is phosphorylated on serine 74 by the ataxia-telangiectasia mutated kinase | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NTP + deoxycytidine | - |
Homo sapiens | NDP + dCMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dCK | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the phosphorylated and activated enzyme can inhibit ionizing radiation-induced cell death including apoptosis and mitotic catastrophe, and promote ionizing radiation-induced autophagy through PI3K/Akt/mTOR pathway. The enzyme is required for the G2/M cell cycle checkpoint and to protect cells against mitotic catastrophe | Homo sapiens |