Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3)pLysS cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with 5-methyldeoxycytidine and ADP, hanging drop vapor diffusion method | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A100V/R104M/D133S | the mutant shows exquisitely high activity for D-deoxycytidine and D-thymidine | Homo sapiens |
A100V/R104M/D133S/E196A | the mutant shows low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
A100V/R104M/D133S/E196L | inactive | Homo sapiens |
A100V/R104M/D133S/F96D | inactive | Homo sapiens |
A100V/R104M/D133S/F96Y | the mutant shows low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
A100V/R104M/D133S/W58E | inactive | Homo sapiens |
A100V/R104M/D133S/W58V | the mutant shows low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
R104M/D133N | the mutant shows low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
R104M/D133N/A138I | inactive | Homo sapiens |
R104M/D133N/L102Y | the mutant shows low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
R104M/D133N/L191A | the mutant shows low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
R104M/D133N/M85Y | the mutant shows low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
R104M/D133N/P89F | inactive | Homo sapiens |
R104M/D133N/V130T | the mutant shows low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
R104M/D133N/V130T/L191A | the mutant shows low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
R104M/D133N/V55E | the mutant shows very low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
R104M/D133N/V55F | the mutant shows very low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
R104M/D133N/V55F/V130T | the mutant shows very low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
R104M/D133N/V55F/V130T/L191A | the mutant shows very low activity for D-deoxycytidine and D-thymidine | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27707 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose resin column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxycytidine | - |
Homo sapiens | ADP + dCMP | - |
? | |
ATP + thymidine | - |
Homo sapiens | ADP + L-dTMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
2'-deoxycytidine kinase | - |
Homo sapiens |
dCK | - |
Homo sapiens |