BRENDA - Reference to 2.7.1.74; Id = 721556

aphidicolin

increases dCK activity via Ser74 phosphorylation, effect of aphidicolin treatment on dCK activity in leukemic cells with substrate deoxycytidine and cladribine and other substrates, overview

Homo sapiens

additional information

deoxycytidine kinase is a key enzyme in the activation of several therapeutic nucleoside analogues

Homo sapiens

S74E

site-directed mutagenesis, the mutation sensitizes the enzyme to feedback inhibition by dCTP, regardless of the phosphoryl donor. Mimicking Ser74 phosphorylation by a S74E mutation increases the enzyme activity toward pyrimidine analogues. The S74E mutation increased the kcat for cladribine by 8 or 3fold, depending on whether the phosphoryl donor was ATP or UTP, for clofarabine by about 2fold with both ATP and UTP, and for fludarabine by 2fold, but only with UTP

Homo sapiens

dCTP

a potent inhibitor of the enzyme when ATP is the phosphoryl donor, but a relatively weak inhibitor when the enzyme activity is measured with UTP as the phosphoryl donor. Inhibition is higher with respect to cladribine than deoxycytidine

Homo sapiens

0.00007

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.00009

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.00018

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.00027

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

0.00065

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.0016

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.0024

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.0087

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.0155

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

0.0155

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.022

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.028

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.0325

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

0.142

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.45

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.551

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

cytosol

-

Homo sapiens

5829

-

Mg2+

required

Homo sapiens

ATP + cladribine

Homo sapiens

-

ADP + cladribine 5'-phosphate

-

?

ATP + clofarabine

Homo sapiens

-

ADP + clofarabine 5'-phosphate

-

?

ATP + deoxyadenosine

Homo sapiens

-

ADP + dAMP

-

?

ATP + deoxycytidine

Homo sapiens

-

ADP + dCMP

-

?

ATP + deoxyguanosine

Homo sapiens

-

ADP + dGMP

-

?

ATP + fludarabine

Homo sapiens

-

ADP + fludarabine 5'-phosphate

-

?

UTP + cladribine

Homo sapiens

-

UDP + cladribine 5'-phosphate

-

?

UTP + clofarabine

Homo sapiens

-

UDP + clofarabine 5'-phosphate

-

?

UTP + deoxyadenosine

Homo sapiens

-

UDP + dAMP

-

?

UTP + deoxycytidine

Homo sapiens

-

UDP + dCMP

-

?

UTP + deoxyguanosine

Homo sapiens

-

UDP + dGMP

-

?

UTP + fludarabine

Homo sapiens

-

UDP + phospho-fludarabine

-

?

Homo sapiens

-

phosphoprotein

phosphorylation of deoxycytidine kinase on Ser74 increases the enzyme activity, increasing dCK activity via Ser74 phosphorylation, e.g. by aphidicolin, can enhance the intracellular activation of some nucleoside analogs, like gemcitabine, but not of cladribine or fludarabine, overview

Homo sapiens

chronic lymphocytic leukemia cell

-

Homo sapiens

-

HCT-116 cell

-

Homo sapiens

-

HT-29 cell

-

Homo sapiens

-

leukemia cell

-

Homo sapiens

-

ATP + cladribine

-

721556

Homo sapiens

ADP + cladribine 5'-phosphate

-

?

ATP + clofarabine

-

721556

Homo sapiens

ADP + clofarabine 5'-phosphate

-

?

ATP + deoxyadenosine

-

721556

Homo sapiens

ADP + dAMP

-

?

ATP + deoxycytidine

-

721556

Homo sapiens

ADP + dCMP

-

?

ATP + deoxyguanosine

-

721556

Homo sapiens

ADP + dGMP

-

?

ATP + fludarabine

-

721556

Homo sapiens

ADP + fludarabine 5'-phosphate

-

?

additional information

deoxycytidine kinase shows broad substrate specificity, catalyzing the phosphorylation of deoxycytidine, deoxyadenosine, and deoxyguanosine with ATP or UTP as phosphoryl donor

721556

Homo sapiens

?

-

UTP + cladribine

-

721556

Homo sapiens

UDP + cladribine 5'-phosphate

-

?

UTP + clofarabine

-

721556

Homo sapiens

UDP + clofarabine 5'-phosphate

-

?

UTP + deoxyadenosine

-

721556

Homo sapiens

UDP + dAMP

-

?

UTP + deoxycytidine

-

721556

Homo sapiens

UDP + dCMP

-

?

UTP + deoxyguanosine

-

721556

Homo sapiens

UDP + dGMP

-

?

UTP + fludarabine

-

721556

Homo sapiens

UDP + phospho-fludarabine

-

?

dCK

-

Homo sapiens

37

-

assay at

Homo sapiens

0.015

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.021

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.0804

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.123

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.172

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.177

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.183

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

0.211

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.363

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.486

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.88

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

1.005

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

1.11

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

1.334

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

1.386

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

2.45

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

7.6

-

assay at

Homo sapiens

ATP

-

Homo sapiens

UTP

-

Homo sapiens

0.0015

-

dCTP

pH 7.6, 37°C, enzyme mutant S74E, with substrates cladribine and ATP, mixed inhibition

Homo sapiens

0.0029

-

dCTP

pH 7.6, 37°C, enzyme mutant S74E, with substrates deoxycytidine and ATP, mixed inhibition

Homo sapiens

0.0058

-

dCTP

pH 7.6, 37°C, wild-type enzyme, with substrates cladribine and ATP, mixed inhibition

Homo sapiens

0.027

-

dCTP

pH 7.6, 37°C, enzyme mutant S74E, with substrates cladribine and UTP, uncompetitive inhibition

Homo sapiens

0.03

-

dCTP

pH 7.6, 37°C, wild-type enzyme, with substrates deoxycytidine and ATP, mixed inhibition

Homo sapiens

0.05

-

dCTP

pH 7.6, 37°C, wild-type enzyme, with substrates cladribine and UTP, uncompetitive inhibition

Homo sapiens

0.052

-

dCTP

pH 7.6, 37°C, enzyme mutant S74E, with substrates deoxycytidine and UTP, uncompetitive inhibition

Homo sapiens

0.398

-

dCTP

pH 7.6, 37°C, wild-type enzyme, with substrates deoxycytidine and UTP, uncompetitive inhibition

Homo sapiens

aphidicolin

increases dCK activity via Ser74 phosphorylation, effect of aphidicolin treatment on dCK activity in leukemic cells with substrate deoxycytidine and cladribine and other substrates, overview

Homo sapiens

additional information

deoxycytidine kinase is a key enzyme in the activation of several therapeutic nucleoside analogues

Homo sapiens

ATP

-

Homo sapiens

UTP

-

Homo sapiens

S74E

site-directed mutagenesis, the mutation sensitizes the enzyme to feedback inhibition by dCTP, regardless of the phosphoryl donor. Mimicking Ser74 phosphorylation by a S74E mutation increases the enzyme activity toward pyrimidine analogues. The S74E mutation increased the kcat for cladribine by 8 or 3fold, depending on whether the phosphoryl donor was ATP or UTP, for clofarabine by about 2fold with both ATP and UTP, and for fludarabine by 2fold, but only with UTP

Homo sapiens

dCTP

a potent inhibitor of the enzyme when ATP is the phosphoryl donor, but a relatively weak inhibitor when the enzyme activity is measured with UTP as the phosphoryl donor. Inhibition is higher with respect to cladribine than deoxycytidine

Homo sapiens

0.0015

-

dCTP

pH 7.6, 37°C, enzyme mutant S74E, with substrates cladribine and ATP, mixed inhibition

Homo sapiens

0.0029

-

dCTP

pH 7.6, 37°C, enzyme mutant S74E, with substrates deoxycytidine and ATP, mixed inhibition

Homo sapiens

0.0058

-

dCTP

pH 7.6, 37°C, wild-type enzyme, with substrates cladribine and ATP, mixed inhibition

Homo sapiens

0.027

-

dCTP

pH 7.6, 37°C, enzyme mutant S74E, with substrates cladribine and UTP, uncompetitive inhibition

Homo sapiens

0.03

-

dCTP

pH 7.6, 37°C, wild-type enzyme, with substrates deoxycytidine and ATP, mixed inhibition

Homo sapiens

0.05

-

dCTP

pH 7.6, 37°C, wild-type enzyme, with substrates cladribine and UTP, uncompetitive inhibition

Homo sapiens

0.052

-

dCTP

pH 7.6, 37°C, enzyme mutant S74E, with substrates deoxycytidine and UTP, uncompetitive inhibition

Homo sapiens

0.398

-

dCTP

pH 7.6, 37°C, wild-type enzyme, with substrates deoxycytidine and UTP, uncompetitive inhibition

Homo sapiens

0.00007

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.00009

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.00018

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.00027

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

0.00065

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.0016

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.0024

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.0087

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.0155

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

0.0155

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.022

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.028

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.0325

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

0.142

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.45

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.551

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

cytosol

-

Homo sapiens

5829

-

Mg2+

required

Homo sapiens

ATP + cladribine

Homo sapiens

-

ADP + cladribine 5'-phosphate

-

?

ATP + clofarabine

Homo sapiens

-

ADP + clofarabine 5'-phosphate

-

?

ATP + deoxyadenosine

Homo sapiens

-

ADP + dAMP

-

?

ATP + deoxycytidine

Homo sapiens

-

ADP + dCMP

-

?

ATP + deoxyguanosine

Homo sapiens

-

ADP + dGMP

-

?

ATP + fludarabine

Homo sapiens

-

ADP + fludarabine 5'-phosphate

-

?

UTP + cladribine

Homo sapiens

-

UDP + cladribine 5'-phosphate

-

?

UTP + clofarabine

Homo sapiens

-

UDP + clofarabine 5'-phosphate

-

?

UTP + deoxyadenosine

Homo sapiens

-

UDP + dAMP

-

?

UTP + deoxycytidine

Homo sapiens

-

UDP + dCMP

-

?

UTP + deoxyguanosine

Homo sapiens

-

UDP + dGMP

-

?

UTP + fludarabine

Homo sapiens

-

UDP + phospho-fludarabine

-

?

phosphoprotein

phosphorylation of deoxycytidine kinase on Ser74 increases the enzyme activity, increasing dCK activity via Ser74 phosphorylation, e.g. by aphidicolin, can enhance the intracellular activation of some nucleoside analogs, like gemcitabine, but not of cladribine or fludarabine, overview

Homo sapiens

chronic lymphocytic leukemia cell

-

Homo sapiens

-

HCT-116 cell

-

Homo sapiens

-

HT-29 cell

-

Homo sapiens

-

leukemia cell

-

Homo sapiens

-

ATP + cladribine

-

721556

Homo sapiens

ADP + cladribine 5'-phosphate

-

?

ATP + clofarabine

-

721556

Homo sapiens

ADP + clofarabine 5'-phosphate

-

?

ATP + deoxyadenosine

-

721556

Homo sapiens

ADP + dAMP

-

?

ATP + deoxycytidine

-

721556

Homo sapiens

ADP + dCMP

-

?

ATP + deoxyguanosine

-

721556

Homo sapiens

ADP + dGMP

-

?

ATP + fludarabine

-

721556

Homo sapiens

ADP + fludarabine 5'-phosphate

-

?

additional information

deoxycytidine kinase shows broad substrate specificity, catalyzing the phosphorylation of deoxycytidine, deoxyadenosine, and deoxyguanosine with ATP or UTP as phosphoryl donor

721556

Homo sapiens

?

-

UTP + cladribine

-

721556

Homo sapiens

UDP + cladribine 5'-phosphate

-

?

UTP + clofarabine

-

721556

Homo sapiens

UDP + clofarabine 5'-phosphate

-

?

UTP + deoxyadenosine

-

721556

Homo sapiens

UDP + dAMP

-

?

UTP + deoxycytidine

-

721556

Homo sapiens

UDP + dCMP

-

?

UTP + deoxyguanosine

-

721556

Homo sapiens

UDP + dGMP

-

?

UTP + fludarabine

-

721556

Homo sapiens

UDP + phospho-fludarabine

-

?

37

-

assay at

Homo sapiens

0.015

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.021

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.0804

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.123

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.172

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

0.177

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.183

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

0.211

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.363

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

0.486

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

0.88

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

1.005

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

1.11

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

1.334

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

1.386

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

2.45

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

7.6

-

assay at

Homo sapiens

additional information

deoxycytidine kinase is a key enzyme in the activation of several therapeutic nucleoside analogues

Homo sapiens

additional information

deoxycytidine kinase is a key enzyme in the activation of several therapeutic nucleoside analogues

Homo sapiens

1.8

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

2.6

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

3

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

6.4

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

50.1

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

56.3

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

57.6

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

74.3

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

76.8

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

90.2

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

130

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

136

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

236

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

257

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

676

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

745

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

1.8

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

2.6

-

fludarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

3

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

6.4

-

fludarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

50.1

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

56.3

-

clofarabine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

57.6

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

74.3

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

76.8

-

clofarabine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

90.2

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

130

-

cladribine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

136

-

cladribine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

236

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate ATP

Homo sapiens

257

-

deoxycytidine

pH 7.6, 37°C, wild-type enzyme, with co-substrate UTP

Homo sapiens

676

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate ATP

Homo sapiens

745

-

deoxycytidine

pH 7.6, 37°C, enzyme mutant S74E, with co-substrate UTP

Homo sapiens

739449

Koduvayur

Targeted delivery of deoxycyti ...

Homo sapiens

PLoS ONE

11

e0157114

2016

-

1

-

1

-

1

-

1

-

4

-

1

-

1

-

1

-

1

-

4

-

1

-

738175

Yamanishi

Melatonin overcomes resistance ...

Homo sapiens

Exp. Hematol.

43

207-214

2015

-

1

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Biochemistry

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Pauwels

The relation between deoxycyti ...

Homo sapiens

BMC Cancer

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Immunohistochemical and geneti ...

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Enhanced activity of deoxycyti ...

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Nucleosides Nucleotides Nucleic Acids

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Cell cycle dependent regulatio ...

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Docking simulation with a puri ...

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Hubeek

Immunocytochemical detection o ...

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Anabolism of amdoxovir: phosph ...

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Animal deoxyribonucleoside kin ...

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Hubeek

Immunocytochemical detection o ...

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Phosphorylation of isocarbosty ...

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1

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1

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1

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1

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2

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2

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1

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1

-

4

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1

-

1

-

1

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1

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2

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671911

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Activation of deoxycytidine ki ...

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6

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3

-

9

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1

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1

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2

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10

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1

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2

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6

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2

-

3

-

9

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1

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2

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10

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641955

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Cytotoxic activity of 2',2'-di ...

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661453

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1

-

1

2

1

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2

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1

-

1

-

1

-

7

1

-

22

1

2

-

3

-

1

3

-

1

-

1

2

1

-

2

-

1

-

7

1

-

22

1

-

641954

Csapo

Activation of deoxycytidine ki ...

Homo sapiens

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191-197

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1

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2

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1

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2

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1

-

1

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2

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641972

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Modulation of human deoxycytid ...

Homo sapiens

Acta Biochim. Pol.

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2

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641969

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Effect of phosphorylation on d ...

Homo sapiens

Adv. Exp. Med. Biol.

486

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-

1

-

1

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1

-

1

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1

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640557

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Low enantioselectivities of hu ...

Homo sapiens

Biochimie

81

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2

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1

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1

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641956

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6

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1

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2

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3

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6

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1

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3

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641959

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Stereoisomeric selectivity of ...

Homo sapiens

Biochemistry

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1999

-

3

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1

-

1

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641965

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Substrate/inhibitor properties ...

Homo sapiens

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18

1883-1903

1999

-

4

-

2

-

2

-

12

-

4

-

4

-

2

-

12

-

641971

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Study of human deoxycytidine k ...

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1

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1

-

1

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1

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1

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1

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1

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1

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1

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641960

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The intracellular localization ...

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2

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2

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2

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641968

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4

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2

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2

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4

-

2

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641958

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Kinetic analysis of human deox ...

Homo sapiens

Biochemistry

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1

-

4

5

-

2

-

1

-

3

-

4

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1

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4

5

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3

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641961

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The effects of high salt conce ...

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1

-

1

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2

-

2

-

1

-

1

-

1

-

2

-

1

-

641963

Eriksson

-

Substrate specificities, expre ...

Homo sapiens

Nucleosides Nucleotides

16

653-659

1997

-

1

-

1

-

1

-

5

-

1

-

1

-

5

-

641964

Shafiee

-

Study of the enantioselectivit ...

Homo sapiens

Nucleosides Nucleotides

16

1767-1770

1997

-

1

-

1

-

1

-

1

-

1

-

641953

Johansson

Differences in kinetic propert ...

Homo sapiens, Mus musculus

Biochem. Pharmacol.

50

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1995

-

2

-

2

20

-

5

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10

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2

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2

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20

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10

-

641967

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Purification of deoxycytidine ...

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28

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2

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1

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2

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3

1

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2

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2

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3

1

-

640566

Ikeda

Heterodimeric deoxynucleoside ...

Lactobacillus acidophilus

Biochemistry

33

5328-5334

1994

-

1

2

-

1

-

1

-

4

1

-

1

2

-

1

-

4

1

-

641938

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Purification and characterizat ...

Homo sapiens

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1993

5

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14

3

2

-

2

-

2

-

1

-

3

2

-

23

1

-

1

-

5

-

14

-

3

2

-

2

-

1

-

3

2

-

23

1

-

641946

Shewach

Nucleotide specificity of huma ...

Homo sapiens

Mol. Pharmacol.

42

518-524

1992

-

1

-

2

-

2

-

6

-

1

-

2

-

6

-

641939

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Homo sapiens

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2

-

2

1

-

1

-

2

1

-

1

-

641947

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Deoxynucleoside phosphorylatin ...

Aotus trivirgatus, Homo sapiens, Mus musculus

Biochem. Pharmacol.

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1991

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9

-

1

3

-

7

-

1

-

12

-

10

2

-

9

-

1

3

-

1

-

12

-

10

2

-

641937

Kierdaszuk

Selective inactivation of the ...

Homo sapiens

Biochemistry

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1990

3

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2

1

-

1

-

1

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3

-

3

-

1

6

-

1

3

-

3

-

2

-

1

-

1

-

1

-

1

-

3

-

1

6

-

1

3

-

641940

Kim

Human deoxycytidine kinase: ki ...

Homo sapiens

Biochemistry

28

9043-9047

1989

-

2

1

-

1

-

2

-

1

-

1

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2

-

1

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2

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1

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1

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1

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2

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1

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641941

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Kinetic properties and inhibit ...

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22

6

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1

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2

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1

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3

1

-

6

-

1

-

22

-

6

-

1

-

1

-

3

1

-

6

-

1

-

641942

Datta

Human T-lymphoblast deoxycytid ...

Homo sapiens

Biochemistry

28

114-123

1989

-

2

11

5

-

8

2

-

3

-

1

-

3

4

1

11

1

-

1

-

1

-

2

-

11

-

5

-

8

2

-

1

-

3

4

1

11

1

-

1

-

641943

Bohman

Deoxycytidine kinase from huma ...

Homo sapiens

Biochemistry

27

4258-4265

1988

1

-

4

5

1

2

-

2

-

1

-

4

1

2

7

1

-

1

-

1

-

1

-

4

-

5

1

2

-

1

-

4

1

2

7

1

-

1

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641944

Kim

Affinity purification of human ...

Homo sapiens

Biochem. Biophys. Res. Commun.

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1988

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3

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1

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2

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1

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1

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10

1

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1

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3

-

1

-

1

-

1

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10

1

-

641079

Yamada

Purine nucleoside kinases in h ...

Homo sapiens

Biochim. Biophys. Acta

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1983

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15

3

1

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2

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5

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4

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15

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3

1

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5

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4

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641936

Ives

Deoxycytidine kinase from calf ...

Bos taurus

Methods Enzymol.

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337-345

1978

-

3

5

1

8

1

-

1

-

1

-

1

2

7

-

1

-

1

-

1

-

3

-

5

-

1

8

1

-

1

-

1

2

7

-

1

-

1

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1

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641945

Baxter

A general method for purificat ...

Bos taurus, Homo sapiens, Sus scrofa

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3

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4

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3

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8

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3

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3

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3

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3

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8

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3

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3

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641950

Deibler

Deoxynucleoside kinases from L ...

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9

1

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1

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1

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1

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1

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5

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641933

Meyers

Purification of deoxycytidine ...

Mus musculus

Arch. Biochem. Biophys.

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10-15

1976

1

-

1

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2

1

-

1

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1

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2

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2

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1

-

2

-

1

-

1

-

2

1

-

1

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2

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2

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1

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2

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641935

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Deoxycytidine kinase from calf ...

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6

3

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1

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1

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1

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11

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1

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6

-

3

-

1

-

1

-

11

-

1

-

641948

Coleman

Deoxycytidine kinase: properti ...

Homo sapiens

Blood

46

791-803

1975

-

3

2

-

1

-

2

-

1

-

2

-

4

-

3

-

2

-

1

-

1

-

2

-

4

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641949

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Mitochondrial and herpesvirus- ...

Aotus trivirgatus, Gallus gallus, Mus musculus

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486-497

1975

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9

-

3

-

3

-

3

-

9

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3

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3

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677714

Wachsman

Demonstration of a deoxycytidi ...

Bacillus megaterium, Bacillus megaterium KM / ATCC 13632

Appl. Microbiol.

25

506-508

1973

-

1

-

12

-

12

-

1

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1

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12

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641934

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Metabolism in deoxyribonucleot ...

Bos taurus

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1972

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21

3

1

5

-

1

-

1

-

1

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13

-

1

-

1

-

21

-

3

1

5

-

1

-

1

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13

-

1

-

1

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641931

Durham

Deoxycytidine kinase. II. Puri ...

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2

-

1

22

-

10

1

-

1

-

1

-

1

2

9

-

1

-

2

-

1

-

3

-

2

-

1

-

22

-

10

1

-

1

-

1

2

9

-

1

-

2

-

1

-

3

-

641932

Ives

Deoxycytidine kinase. 3. Kinet ...

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3

-

1

-

1

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1

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4

-

1

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1

-

1

-

4

-

1

-

641929

Kessel

Properties of deoxycytidine ki ...

Mus musculus

J. Biol. Chem.

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1968

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2

16

1

6

1

-

1

-

1

-

1

3

6

-

1

2

-

1

-

2

-

16

-

1

6

1

-

1

-

1

3

6

-

1

2

-

1

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641930

Momparler

Mammalian deoxynucleoside kina ...

Bos taurus

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1

-

8

5

1

3

-

1

-

1

-

1

-

7

-

1

-

1

-

8

-

5

1

3

-

1

-

1

-

7

-

1

-

Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells

Data extracted from this reference: