BRENDA - Enzyme Database show
show all sequences of 2.7.1.74

Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: Illuminating the role of main-chain reorganization

Godsey, M.H.; Ort, S.; Sabini, E.; Konrad, M.; Lavie, A.; Biochemistry 45, 452-461 (2006)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed of engineered protein as His-tag fusion protein in Escherichia coli
Homo sapiens
Crystallization (Commentary)
Crystallization
Organism
hanging drop vapour diffusion method, in complex with deoxycytidine (dC) and UDP, and in the presence of deoxycytidine but the absence of UDP or ADP
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
DEL65-79
construction of an enzyme variant lacking a flexible insert (residues 65-79) but having similar catalytic properties as the wild type
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.001
-
2'-deoxycytidine
less than 0.001 mM, residues 65-79 deletion mutant with UTP as cosubstrate; less than 0.001 mM, wild type enzyme with ATP as cosubstrate; less than 0.001 mM, wild type enzyme with UTP as cosubstrate
Homo sapiens
0.0014
-
2'-deoxycytidine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
0.0015
-
UTP
residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.0023
-
UTP
wild type enzyme deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.0029
-
ATP
residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.003
-
1-beta-D-arabinofuranosylcytosine
residues 65-79 deletion mutant with UTP as cosubstrate; wild type enzyme with UTP as cosubstrate
Homo sapiens
0.0035
-
ATP
wild type enzyme with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.0047
-
UTP
residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.007
-
1-beta-D-arabinofuranosylcytosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
0.01
-
UTP
wild type enzyme deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.013
-
1-beta-D-arabinofuranosylcytosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
0.013
-
2'-deoxyadenosine
wild type enzyme with UTP as cosubstrate
Homo sapiens
0.021
-
2'-deoxyguanosine
wild type enzyme with UTP as cosubstrate
Homo sapiens
0.053
-
2'-deoxyadenosine
residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.053
-
ATP
residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.087
-
2'-deoxyguanosine
residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.093
-
ATP
wild type enzyme with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.1
-
2'-deoxyadenosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
0.231
-
2'-deoxyguanosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
0.415
-
2'-deoxyadenosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
0.474
-
2'-deoxyguanosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
30500
-
2 * 30500, calculated from the deduced amino acid sequence, crystal structure analysis
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
NTP + 1-beta-D-arabinofuranosylcytosine
Homo sapiens
antineoplastic agent
NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
-
-
?
NTP + 2',3'-dideoxycytidine
Homo sapiens
antiviral agent
NDP + 2',3'-dideoxycytidine 5'-phosphate
-
-
?
NTP + 2'-deoxy-3'-thiacytidine
Homo sapiens
antiviral agent
NDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
-
?
NTP + 2'-deoxyadenosine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides
NDP + 2'-deoxyadenosine 5'-phosphate
-
-
?
NTP + 2'-deoxycytidine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides
NDP + 2'-deoxycytidine 5'-phosphate
-
-
?
NTP + 2'-deoxyguanosine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides
NDP + 2'-deoxyguanosine 5'-phosphate
-
-
?
NTP + 2-chloro-2'-deoxyadenosine
Homo sapiens
i.e. cladribine, antineoplastic agent
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P27707
-
-
Purification (Commentary)
Commentary
Organism
recombinant protein using His-tag
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
NTP + 1-beta-D-arabinofuranosylcytosine
antineoplastic agent
672149
Homo sapiens
NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
-
-
-
?
NTP + 2',3'-dideoxycytidine
antiviral agent
672149
Homo sapiens
NDP + 2',3'-dideoxycytidine 5'-phosphate
-
-
-
?
NTP + 2'-deoxy-3'-thiacytidine
antiviral agent
672149
Homo sapiens
NDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
-
-
?
NTP + 2'-deoxyadenosine
rate-limiting reaction in the salvage of deoxyribonucleosides
672149
Homo sapiens
NDP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
NTP + 2'-deoxycytidine
rate-limiting reaction in the salvage of deoxyribonucleosides
672149
Homo sapiens
NDP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
NTP + 2'-deoxyguanosine
rate-limiting reaction in the salvage of deoxyribonucleosides
672149
Homo sapiens
NDP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
NTP + 2-chloro-2'-deoxyadenosine
i.e. cladribine, antineoplastic agent
672149
Homo sapiens
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
Subunits
Subunits
Commentary
Organism
dimer
2 * 30500, calculated from the deduced amino acid sequence, crystal structure analysis
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.028
-
ATP
wild type enzyme with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.031
-
UTP
wild type enzyme deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.033
-
2'-deoxycytidine
less than 0.001 mM, wild type enzyme with ATP as cosubstrate
Homo sapiens
0.039
-
ATP
residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.041
-
UTP
residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.044
-
2'-deoxycytidine
less than 0.001 mM, wild type enzyme with UTP as cosubstrate
Homo sapiens
0.049
-
2'-deoxycytidine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
0.075
-
UTP
residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.088
-
2'-deoxycytidine
less than 0.001 mM, residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.093
-
UTP
wild type enzyme deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.15
-
1-beta-D-arabinofuranosylcytosine
residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.17
-
1-beta-D-arabinofuranosylcytosine
wild type enzyme with UTP as cosubstrate
Homo sapiens
0.3
-
1-beta-D-arabinofuranosylcytosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
0.31
-
2'-deoxyadenosine
residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.32
-
2'-deoxyguanosine
residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.33
-
2'-deoxyadenosine
wild type enzyme with UTP as cosubstrate
Homo sapiens
0.33
-
2'-deoxyguanosine
wild type enzyme with UTP as cosubstrate
Homo sapiens
0.36
-
ATP
residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.4
-
ATP
wild type enzyme with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.41
-
1-beta-D-arabinofuranosylcytosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
1.7
-
2'-deoxyadenosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
2.2
-
2'-deoxyguanosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
2.6
-
2'-deoxyguanosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
2.8
-
2'-deoxyadenosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
UTP
preferred phosphoryl group donor
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed of engineered protein as His-tag fusion protein in Escherichia coli
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
UTP
preferred phosphoryl group donor
Homo sapiens
Crystallization (Commentary) (protein specific)
Crystallization
Organism
hanging drop vapour diffusion method, in complex with deoxycytidine (dC) and UDP, and in the presence of deoxycytidine but the absence of UDP or ADP
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
DEL65-79
construction of an enzyme variant lacking a flexible insert (residues 65-79) but having similar catalytic properties as the wild type
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.001
-
2'-deoxycytidine
less than 0.001 mM, residues 65-79 deletion mutant with UTP as cosubstrate; less than 0.001 mM, wild type enzyme with ATP as cosubstrate; less than 0.001 mM, wild type enzyme with UTP as cosubstrate
Homo sapiens
0.0014
-
2'-deoxycytidine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
0.0015
-
UTP
residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.0023
-
UTP
wild type enzyme deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.0029
-
ATP
residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.003
-
1-beta-D-arabinofuranosylcytosine
residues 65-79 deletion mutant with UTP as cosubstrate; wild type enzyme with UTP as cosubstrate
Homo sapiens
0.0035
-
ATP
wild type enzyme with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.0047
-
UTP
residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.007
-
1-beta-D-arabinofuranosylcytosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
0.01
-
UTP
wild type enzyme deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.013
-
1-beta-D-arabinofuranosylcytosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
0.013
-
2'-deoxyadenosine
wild type enzyme with UTP as cosubstrate
Homo sapiens
0.021
-
2'-deoxyguanosine
wild type enzyme with UTP as cosubstrate
Homo sapiens
0.053
-
2'-deoxyadenosine
residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.053
-
ATP
residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.087
-
2'-deoxyguanosine
residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.093
-
ATP
wild type enzyme with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.1
-
2'-deoxyadenosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
0.231
-
2'-deoxyguanosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
0.415
-
2'-deoxyadenosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
0.474
-
2'-deoxyguanosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
30500
-
2 * 30500, calculated from the deduced amino acid sequence, crystal structure analysis
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
NTP + 1-beta-D-arabinofuranosylcytosine
Homo sapiens
antineoplastic agent
NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
-
-
?
NTP + 2',3'-dideoxycytidine
Homo sapiens
antiviral agent
NDP + 2',3'-dideoxycytidine 5'-phosphate
-
-
?
NTP + 2'-deoxy-3'-thiacytidine
Homo sapiens
antiviral agent
NDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
-
?
NTP + 2'-deoxyadenosine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides
NDP + 2'-deoxyadenosine 5'-phosphate
-
-
?
NTP + 2'-deoxycytidine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides
NDP + 2'-deoxycytidine 5'-phosphate
-
-
?
NTP + 2'-deoxyguanosine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides
NDP + 2'-deoxyguanosine 5'-phosphate
-
-
?
NTP + 2-chloro-2'-deoxyadenosine
Homo sapiens
i.e. cladribine, antineoplastic agent
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant protein using His-tag
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
NTP + 1-beta-D-arabinofuranosylcytosine
antineoplastic agent
672149
Homo sapiens
NDP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
-
-
-
?
NTP + 2',3'-dideoxycytidine
antiviral agent
672149
Homo sapiens
NDP + 2',3'-dideoxycytidine 5'-phosphate
-
-
-
?
NTP + 2'-deoxy-3'-thiacytidine
antiviral agent
672149
Homo sapiens
NDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
-
-
?
NTP + 2'-deoxyadenosine
rate-limiting reaction in the salvage of deoxyribonucleosides
672149
Homo sapiens
NDP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
NTP + 2'-deoxycytidine
rate-limiting reaction in the salvage of deoxyribonucleosides
672149
Homo sapiens
NDP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
NTP + 2'-deoxyguanosine
rate-limiting reaction in the salvage of deoxyribonucleosides
672149
Homo sapiens
NDP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
NTP + 2-chloro-2'-deoxyadenosine
i.e. cladribine, antineoplastic agent
672149
Homo sapiens
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 30500, calculated from the deduced amino acid sequence, crystal structure analysis
Homo sapiens
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.028
-
ATP
wild type enzyme with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.031
-
UTP
wild type enzyme deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.033
-
2'-deoxycytidine
less than 0.001 mM, wild type enzyme with ATP as cosubstrate
Homo sapiens
0.039
-
ATP
residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.041
-
UTP
residues 65-79 deletion mutant with 2'-deoxycytidine as cosubstrate
Homo sapiens
0.044
-
2'-deoxycytidine
less than 0.001 mM, wild type enzyme with UTP as cosubstrate
Homo sapiens
0.049
-
2'-deoxycytidine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
0.075
-
UTP
residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.088
-
2'-deoxycytidine
less than 0.001 mM, residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.093
-
UTP
wild type enzyme deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.15
-
1-beta-D-arabinofuranosylcytosine
residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.17
-
1-beta-D-arabinofuranosylcytosine
wild type enzyme with UTP as cosubstrate
Homo sapiens
0.3
-
1-beta-D-arabinofuranosylcytosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
0.31
-
2'-deoxyadenosine
residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.32
-
2'-deoxyguanosine
residues 65-79 deletion mutant with UTP as cosubstrate
Homo sapiens
0.33
-
2'-deoxyadenosine
wild type enzyme with UTP as cosubstrate
Homo sapiens
0.33
-
2'-deoxyguanosine
wild type enzyme with UTP as cosubstrate
Homo sapiens
0.36
-
ATP
residues 65-79 deletion mutant with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.4
-
ATP
wild type enzyme with 1-beta-D-arabinofuranosylcytosine as cosubstrate
Homo sapiens
0.41
-
1-beta-D-arabinofuranosylcytosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
1.7
-
2'-deoxyadenosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
2.2
-
2'-deoxyguanosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
2.6
-
2'-deoxyguanosine
wild type enzyme with ATP as cosubstrate
Homo sapiens
2.8
-
2'-deoxyadenosine
residues 65-79 deletion mutant with ATP as cosubstrate
Homo sapiens
Other publictions for EC 2.7.1.74
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739449
Koduvayur
Targeted delivery of deoxycyti ...
Homo sapiens
PLoS ONE
11
e0157114
2016
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
4
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
4
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738175
Yamanishi
Melatonin overcomes resistance ...
Homo sapiens
Exp. Hematol.
43
207-214
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739431
Coulibaly
Potent sensitisation of cancer ...
Homo sapiens
PLoS ONE
10
e0140741
2015
-
-
1
-
-
-
-
3
-
-
-
1
-
2
-
-
1
-
-
1
-
-
3
1
-
-
-
3
-
-
-
-
-
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1
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3
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1
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1
-
1
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3
1
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3
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3
737326
Muthu
Redesigning human 2'-deoxycyti ...
Homo sapiens
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2
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19
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737347
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Structural characterization of ...
Homo sapiens
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4
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1
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4
4
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1
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1
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10
1
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Homo sapiens
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1
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1
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5
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1
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Bombyx mori
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1
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1
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1
-
1
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1
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721278
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Homogeneous assay for real-tim ...
Homo sapiens
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1
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1
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1
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1
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1
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722221
Weng
Hypoxia-induced deoxycytidine ...
Homo sapiens, Mus musculus
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3
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2
4
4
2
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Fan
Deoxycytidine kinase promotes ...
Homo sapiens
Int. J. Clin. Exp. Pathol.
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3
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1
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Murphy
Development of new deoxycytidi ...
Homo sapiens
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721556
Amsailale
Phosphorylation of deoxycytidi ...
Homo sapiens
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16
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8
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1
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1
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1
8
16
1
1
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12
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1
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13
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1
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16
1
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1
1
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16
16
723235
Neschadim
Cell fate control gene therapy ...
Homo sapiens
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723298
Yang
Deoxycytidine kinase regulates ...
Homo sapiens
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1
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723345
Ohmine
Attenuation of phosphorylation ...
Homo sapiens
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3
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1
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1
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721636
Hazra
Post-translational phosphoryla ...
Homo sapiens
Biochemistry
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2011
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1
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2
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1
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1
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2
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1
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1
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2
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721969
Nagai
Deoxycytidine kinase modulates ...
Homo sapiens
Cancer Res.
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1
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1
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11
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Novel potent inhibitors of deo ...
Homo sapiens
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8
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706027
Funamizu
Is the resistance of gemcitabi ...
Homo sapiens
Oncol. Rep.
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2010
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706844
Mirzaee
Differences in cytosolic and m ...
Mus musculus, Rattus norvegicus
Toxicology
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2
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2
2
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721622
Hazra
Structural and kinetic charact ...
Homo sapiens
Biochemistry
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2010
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1
1
1
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1
1
1
1
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1
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1
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13
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1
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1
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1
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722913
Hazra
The sugar ring of the nucleosi ...
Homo sapiens
J. Med. Chem.
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Novel PET probes specific for ...
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
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2
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2
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2
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4
2
2
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9
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1
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23
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2
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2
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-
-
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3
3
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723303
Smal
Influence of phosphorylation o ...
Homo sapiens
Nucleosides Nucleotides Nucleic Acids
29
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2010
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1
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6
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1
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1
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6
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1
-
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1
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-
-
-
-
-
-
-
-
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1
1
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723637
Toy
Requirement for deoxycytidine ...
Mus musculus
Proc. Natl. Acad. Sci. USA
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5551-5556
2010
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1
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4
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2
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1
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1
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4
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2
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-
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3
3
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702271
Hazra
Extending thymidine kinase act ...
Homo sapiens
Biochemistry
48
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2009
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1
1
2
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19
1
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6
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19
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1
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1
1
1
2
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19
1
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1
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6
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19
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19
19
702603
Tarver
5-Fluorocytosine derivatives a ...
Mus musculus
Bioorg. Med. Chem. Lett.
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6780-6783
2009
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33
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33
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33
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1
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1
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702604
Jessop
Lead optimization and structur ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
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2009
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23
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23
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1
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703020
Costantino
The role of HuR in gemcitabine ...
Homo sapiens
Cancer Res.
69
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2009
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704900
Shord
Paclitaxel alters the expressi ...
Homo sapiens
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690454
Ohhashi
Down-regulation of deoxycytidi ...
Homo sapiens
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690954
Iyidogan
Systematic exploration of acti ...
Homo sapiens
Biochemistry
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44
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11
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28
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691590
Szatmari
Adenoviral vector transduction ...
Homo sapiens
Cancer Gene Ther.
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1
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Positive regulation of deoxycy ...
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Sabini
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Soriano
Structures of human deoxycytid ...
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Zhang
The structure of human deoxycy ...
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Mani
Fluorescence energy transfer s ...
Homo sapiens
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Godsey
Structural basis for the prefe ...
Homo sapiens
Biochemistry
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Pauwels
The relation between deoxycyti ...
Homo sapiens
BMC Cancer
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Bierau
Cyclopentenyl cytosine-induced ...
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Sebastiani
Immunohistochemical and geneti ...
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Smal
Identification of in vivo phos ...
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Sigmond
Enhanced activity of deoxycyti ...
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Fyrberg
Cell cycle dependent regulatio ...
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Nucleosides Nucleotides Nucleic Acids
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Keszler
Activation of deoxycytidine ki ...
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Rylova
Activity profiles of deoxynucl ...
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Docking simulation with a puri ...
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Hubeek
Immunocytochemical detection o ...
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J. Clin. Pathol.
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Feng
Anabolism of amdoxovir: phosph ...
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Piskur
Animal deoxyribonucleoside kin ...
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Mani
Fluorescence studies of substr ...
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662989
Hubeek
Immunocytochemical detection o ...
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Nucleosides Nucleotides Nucleic Acids
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2004
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662992
Al-Madhoun
Phosphorylation of isocarbosty ...
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Nucleosides Nucleotides Nucleic Acids
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Csapo
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1
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1
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1
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1
6
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1
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641940
Kim
Human deoxycytidine kinase: ki ...
Homo sapiens
Biochemistry
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1989
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Datta
Kinetic properties and inhibit ...
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641942
Datta
Human T-lymphoblast deoxycytid ...
Homo sapiens
Biochemistry
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114-123
1989
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11
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641943
Bohman
Deoxycytidine kinase from huma ...
Homo sapiens
Biochemistry
27
4258-4265
1988
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4
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4
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1
1
2
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1
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4
1
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7
1
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641944
Kim
Affinity purification of human ...
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1988
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3
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1
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1
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1
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10
1
1
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641079
Yamada
Purine nucleoside kinases in h ...
Homo sapiens
Biochim. Biophys. Acta
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34-40
1983
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15
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3
1
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5
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4
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641936
Ives
Deoxycytidine kinase from calf ...
Bos taurus
Methods Enzymol.
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337-345
1978
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3
5
1
1
8
1
1
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1
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1
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1
1
2
7
-
1
-
1
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1
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-
3
-
5
-
1
1
8
1
1
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1
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1
1
2
7
-
1
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1
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1
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641945
Baxter
A general method for purificat ...
Bos taurus, Homo sapiens, Sus scrofa
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1005-1008
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8
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3
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3
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3
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8
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3
-
3
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641950
Deibler
Deoxynucleoside kinases from L ...
Lactobacillus acidophilus
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252
8240-8244
1977
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9
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1
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1
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5
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641933
Meyers
Purification of deoxycytidine ...
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Arch. Biochem. Biophys.
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1976
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2
2
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2
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1
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2
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1
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1
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2
1
1
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1
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2
2
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2
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1
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2
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641935
Krenitsky
Deoxycytidine kinase from calf ...
Bos taurus
J. Biol. Chem.
251
4055-4061
1976
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1
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11
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1
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6
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3
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1
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1
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11
-
1
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641948
Coleman
Deoxycytidine kinase: properti ...
Homo sapiens
Blood
46
791-803
1975
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3
2
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1
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2
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2
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4
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3
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1
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1
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4
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641949
Leung
Mitochondrial and herpesvirus- ...
Aotus trivirgatus, Gallus gallus, Mus musculus
J. Virol.
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1975
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3
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9
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3
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3
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677714
Wachsman
Demonstration of a deoxycytidi ...
Bacillus megaterium, Bacillus megaterium KM / ATCC 13632
Appl. Microbiol.
25
506-508
1973
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1
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12
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12
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1
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12
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641934
Kozai
Metabolism in deoxyribonucleot ...
Bos taurus
J. Biochem.
71
485-496
1972
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1
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1
1
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13
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1
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1
1
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-
-
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21
-
3
1
5
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-
1
-
1
1
-
13
-
1
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1
1
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641931
Durham
Deoxycytidine kinase. II. Puri ...
Bos taurus
J. Biol. Chem.
245
2276-2284
1970
2
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1
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1
1
2
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1
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2
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1
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3
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2
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1
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22
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-
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10
1
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1
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1
1
2
9
-
1
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2
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1
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3
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641932
Ives
Deoxycytidine kinase. 3. Kinet ...
Bos taurus
J. Biol. Chem.
245
2285-2294
1970
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1
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4
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1
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3
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1
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1
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4
-
1
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641929
Kessel
Properties of deoxycytidine ki ...
Mus musculus
J. Biol. Chem.
243
4739-4744
1968
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1
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1
1
3
6
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1
1
2
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1
1
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-
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2
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16
-
1
1
6
1
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1
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1
1
3
6
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1
1
2
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1
1
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641930
Momparler
Mammalian deoxynucleoside kina ...
Bos taurus
J. Biol. Chem.
243
4298-4304
1968
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7
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1
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1
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8
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5
1
3
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1
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1
1
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7
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1
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