Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2'-deoxyadenosine/deoxycoformycin | no stimulation of enzyme activity by either compound if applied alone, with both compound at 0.01 mM 2.4fold activation occurs | Homo sapiens | |
2-chloro-2'-deoxyadenosine | 2.4fold activation at 0.003 mM, activation is slightly inhibited by 3-aminobenzamide, the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity | Homo sapiens | |
aphidicolin | - |
Homo sapiens | |
etoposide | - |
Homo sapiens | |
additional information | enzyme is activated by inhibitors of signal transduction enzymes, overview, deoxycytidine prevents activation of the enzyme, no activation by PD 98059 and SB 203580 in presence of deoxycytidine | Homo sapiens | |
PD 153035 | i.e. 4-(3-bromoanilino)-6,7-dimethoxy-quinazinoline | Homo sapiens | |
PD 98059 | i.e. 2'-amino-3'-methoxyflavone, in absence of deoxycytidine | Homo sapiens | |
SB 203580 | in absence of deoxycytidine | Homo sapiens | |
tyrphostin A47 | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sorbitol | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxycytidine | Homo sapiens | - |
ADP + 2'-deoxycytidine 5'-phosphate | - |
? | |
additional information | Homo sapiens | the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphocyte | tonsillar | Homo sapiens | - |
tonsil | lymphocyte | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxycytidine | - |
Homo sapiens | ADP + 2'-deoxycytidine 5'-phosphate | - |
? | |
ATP + 2-chloro-2'-deoxyadenosine | i.e. cladribine | Homo sapiens | ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate | - |
? | |
additional information | the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity | Homo sapiens | ? | - |
? | |
additional information | the enzyme shows broad substrate specificity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dCK | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |