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Literature summary for 2.7.1.74 extracted from

  • Kierdaszuk, B.; Krawiec, K.; Kazimierczuk, Z.; Jacobsson, U.; Johansson, N.G.; Munch-Petersen, B.; Eriksson, S.; Shugar, D.
    Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O'-alkyl analogues (1999), Nucleosides Nucleotides, 18, 1883-1903.
    View publication on PubMed
Search for more literature for 2.7.1.74

Inhibitors

Inhibitors Comment Organism Structure
2'-O-methylcytidine
-
 Homo sapiens
3'-O-methyl-2'deoxycytidine
-
 Homo sapiens
5'-O-ethyl-2'-deoxycytidine
-
 Homo sapiens
5'-O-methyl-2'-deoxycytidine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukemia cell from spleen Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',2'-difluoro-2'-deoxyguanosine + ATP
-
 Homo sapiens ADP + 2',2'-difluoro-2'-deoxyguanosine 5'-phosphate
-
 ?
2'-fluoro-2'-deoxyarabinosylcytidine + ATP
-
 Homo sapiens ADP + 2'-fluoro-2'-deoxyarabinosylcytidine 5'-phosphate
-
 ?
2'-fluoro-2'-deoxycytidine + ATP
-
 Homo sapiens ADP + 2'-fluoro-2'-deoxycytidine 5'-phosphate
-
 ?
2'-O-methyl-cytidine + ATP
-
 Homo sapiens ADP + 2'-O-methyl-cytidine 5'-phosphate
-
 ?
2-chloro-2'-deoxyadenosine + NTP
-
 Homo sapiens NDP + 2-chloro-2'-deoxy-AMP
-
 ?
3'-O-methyl-2'-deoxycytidine + ATP
-
 Homo sapiens ADP + 3'-O-methyl-2'-deoxycytidine 5'-phosphate
-
 ?
9-(beta-D-arabinofuranosyl)-adenine + ATP
-
 Homo sapiens 9-(beta-D-arabinofuranosyl)-adenine 5'-phosphate + ADP
-
 ?
beta-D-3'-hydroxymethyl-2',3'dideoxycytidine + ATP
-
 Homo sapiens ADP + beta-D-3'-hydroxymethyl-2',3'dideoxycytidine 5'-phosphate
-
 ?
NTP + cytosine arabinoside
-
 Homo sapiens NDP + cytosine arabinoside 5'-monophosphate
-
 ?
NTP + deoxyadenosine
-
 Homo sapiens NDP + dAMP
-
 ?
NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?
NTP + deoxyguanosine
-
 Homo sapiens NDP + dGMP
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.02
-
 3'-O-methyl-2'deoxycytidine 37°C, pH 7.6 Homo sapiens
0.032
-
 5'-O-ethyl-2'-deoxycytidine 37°C, pH 7.6 Homo sapiens
0.23
-
 5'-O-methyl-2'-deoxycytidine 37°C, pH 7.6 Homo sapiens
0.3
-
 2'-O-methylcytidine 37°C, pH 7.6 Homo sapiens