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Literature summary for 2.7.1.71 extracted from

  • Arora, N.; Banerjee, A.K.; Murty, U.S.
    In silico characterization of shikimate kinase of Shigella flexneri: a potential drug target (2010), Interdiscip. Sci., 2, 280-290.
    View publication on PubMed
Search for more literature for 2.7.1.71

Application

Application Comment Organism
drug development the enzyme is an attractive drug target Shigella flexneri

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme structure analysis and modeling for rational drug designing, overview Shigella flexneri

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Shigella flexneri

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + shikimate Shigella flexneri
-
 ADP + 3-phosphoshikimate
-
 ?
ATP + shikimate Shigella flexneri 8401
-
 ADP + 3-phosphoshikimate
-
 ?

Organism

Organism UniProt Comment Textmining
Shigella flexneri
-
 serotype 5b
-
Shigella flexneri 8401
-
 serotype 5b
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + shikimate
-
 Shigella flexneri ADP + 3-phosphoshikimate
-
 ?
ATP + shikimate
-
 Shigella flexneri 8401 ADP + 3-phosphoshikimate
-
 ?

Subunits

Subunits Comment Organism
? x * 26973.6, sequence calculation Shigella flexneri
More prediction of enzyme secondary sstructure, overview Shigella flexneri

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Shigella flexneri

pI Value

Organism Comment pI Value Maximum pI Value
Shigella flexneri sequence calculation
-
 5.61

General Information

General Information Comment Organism
additional information comparative modeling approach, molecular dynamics calculations using the Escherichia coli structure as template, prediction of in silico and disordered regions, enzyme structure analysis and modeling, overview Shigella flexneri