Cloned (Comment) | Organism |
---|---|
expressed as His6-tagged protein in Escherichia coli BL21(DE3) cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 95000, isoform PIPKIgammai5, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PIPKIgammai5 | - |
Homo sapiens |
type I gamma phosphatidylinositol phosphate 5-kinase i5 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of isoform PIPKIgammai5 leads to the loss of mitogen-inducible gene 6 expression, which dramatically enhances and prolongs epidermal growth factor receptor-mediated cell signaling | Homo sapiens |
physiological function | isoform PIPKIgammai5 controls Mig6 ubiquitination and degradation. Isoform PIPKIgammai5, the E3 ubiquitin ligase neuronal precursor cell-expressed developmentally down-regulated 4-1, and mitogen-inducible gene 6 form a molecular nexus that controls epidermal growth factor receptor activation and downstream signalling | Homo sapiens |