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Literature summary for 2.7.1.68 extracted from

  • Muscolini, M.; Camperio, C.; Capuano, C.; Caristi, S.; Piccolella, E.; Galandrini, R.; Tuosto, L.
    Phosphatidylinositol 4-phosphate 5-kinase alpha activation critically contributes to CD28-dependent signaling responses (2013), J. Immunol., 190, 5279-5286.
    View publication on PubMed
Search for more literature for 2.7.1.68

Activating Compound

Activating Compound Comment Organism Structure
CD28 CD28 recruits and activates the enzyme Homo sapiens

Protein Variants

Protein Variants Comment Organism
D310K inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:CD4+ cell
-
 Homo sapiens
-
T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 4-phosphate 5-kinase alpha
-
 Homo sapiens
PIP5Kalpha
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme silencing impairs CD28-mediated IL-8 and IL-2 transcriptional activation Homo sapiens
physiological function the enzyme is a key modulator of CD28 costimulatory signals and required for CD28-mediated transcription of both interleukin-8 and interleukin-2 genes Homo sapiens