Protein Variants | Comment | Organism |
---|---|---|
K244A | the mutant protein localizes in the cytosol | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleolus | - |
Homo sapiens | 5730 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | - |
x * 68000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q99755 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
sumoylation | SUMOylation at Lys-244 and Lys-490 directs the enzyme's nuclear entry and its interaction with H3K9me3/HP1-alpha, respectively | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 68000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol-4-phosphate 5-kinase1alpha | - |
Homo sapiens |
PIP5K | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme functions as a member of the rDNA silencing complex | Homo sapiens |