Cloned (Comment) | Organism |
---|---|
expression of isozyme PIP5Kalpha tagged with monomeric red fluorescent protein, haemagglutinin, or FLAG in HEK-293T cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
D309N | inactive mutant | Homo sapiens |
additional information | construction of PIP5Kalpha knockdown BV-2 cells by shRNA | Mus musculus |
R332H | YFP-tagged tubby mutant | Mus musculus |
R427Q | inactive mutant | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma | - |
Mus musculus | P70182 | isozymes PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BV-2 cell | isozymes type I PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma are all expressed in BV-2 microglial cells | Mus musculus | - |
microglial cell | - |
Homo sapiens | - |
microglial cell | isozymes type I PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma are all expressed in BV-2 microglial cells | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 4-phosphate 5-kinase alpha | - |
Homo sapiens |
phosphatidylinositol 4-phosphate 5-kinase alpha | - |
Mus musculus |
PI 4-phosphate 5-kinase | - |
Homo sapiens |
PI 4-phosphate 5-kinase | - |
Mus musculus |
PIP5K | - |
Homo sapiens |
PIP5K | - |
Mus musculus |
PIP5Kalpha | - |
Homo sapiens |
PIP5Kalpha | - |
Mus musculus |
type I PI 4-phosphate 5-kinase | - |
Homo sapiens |
type I PI 4-phosphate 5-kinase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide | Homo sapiens |
malfunction | isozyme PIP5Kalpha knockdown reduces 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels and disrupts Toll/IL-1 receptor domain-containing adaptor protein membrane targeting by lipopolysaccharide. Isozyme PIP5Kalpha shRNA-15 knockdown cells are less effective inducing iNOS protein expression and nitric oxide production after lipopolysaccharide stimulation overnight and for 24 h, respectively, compared with control cells | Mus musculus |
metabolism | phosphorylation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the type I PI 4-phosphate 5-kinase (PIP5K) family members including PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma isoforms is the major pathway of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis in mammalian cells | Homo sapiens |
metabolism | phosphorylation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the type I PI 4-phosphate 5-kinase (PIP5K) family members including PIP5Kalpha, PIP5Kbeta, and PIP5Kgamma isoforms is the major pathway of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis in mammalian cells | Mus musculus |
physiological function | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate regulates many critical cellular events and mediates plasma membrane localization of the Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), required for the MyD88-dependent Toll-like receptor 4 signaling pathway. Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein location | Homo sapiens |
physiological function | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate regulates many critical cellular events and mediates plasma membrane localization of the Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), required for the MyD88-dependent Toll-like receptor 4 signaling pathway. Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates toll-like receptor 4-mediated microglial inflammation through regulation of the toll/interleukin-1 receptor domain-containing adaptor protein location | Mus musculus |