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Literature summary for 2.7.1.68 extracted from

  • Hasegawa, H.; Noguchi, J.; Yamashita, M.; Okada, R.; Sugimoto, R.; Furuya, M.; Unoki, T.; Funakoshi, Y.; Baba, T.; Kanaho, Y.
    Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis (2012), Biol. Reprod., 86:136, 1-12.
    View publication on PubMed
Search for more literature for 2.7.1.68

Protein Variants

Protein Variants Comment Organism
additional information construction of single knockout mutants of isozymes Pip5k1a and Pip5k1b, and double knockout mutants Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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 isozymes PIP5K1A, PIP5K1B, and PIP5K1C
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Source Tissue

Source Tissue Comment Organism Textmining
sperm
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 Mus musculus
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spermatocyte
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 Mus musculus
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Synonyms

Synonyms Comment Organism
phosphatidylinositol 4-phosphate 5-kinase
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 Mus musculus
PIP5K
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 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockoout mutants are infertile, phenotypes, overview. Flagella of sperm from isozyme Pip5k1a knockout mutant and even more of Pip5k1a/Pip5k1b double-knockout mutant mice remarkably undergo morphological changes and impairment, whereas Pip5k1b-knockout mutant sperm is morphologically normal. F-actin organization in the seminiferous epithelium is disrupted by the loss of PIP5K1A and PIP5K1B Mus musculus
physiological function the lipid kinase phosphatidylinositol 4-phosphate 5-kinase produces a versatile signaling phospholipid, phosphatidylinositol 4,5-bisphosphate, isozymes PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis Mus musculus