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Literature summary for 2.7.1.68 extracted from

  • Lokuta, M.A.; Senetar, M.A.; Bennin, D.A.; Nuzzi, P.A.; Chan, K.T.; Ott, V.L.; Huttenlocher, A.
    Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis (2007), Mol. Biol. Cell, 18, 5069-5080.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.68

Protein Variants

Protein Variants Comment Organism
D253A mutant lacking kinase activity. Overexpression compromises uropod formation and rear retraction during chemotaxis Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 isoform phosphatidylinositol 4-phosphate 5-kinase type Igamma
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Mus musculus
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 isoform phosphatidylinositol 4-phosphate 5-kinase type Igamma
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell enzyme is enriched in the uropod during chemotaxis of differentiated HL-60 cells. Enrichment occurs early upon chemoattractant stimulation and is persistent during chemotaxis, concomitant with enrichment of phosphatidylinositol 4,5-bisphosphate Homo sapiens
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neutrophil enzyme is enriched in the uropod during chemotaxis of primary neutrophils. Enrichment occurs early upon chemoattractant stimulation and is persistent during chemotaxis, concomitant with enrichment of phosphatidylinositol 4,5-bisphosphate Homo sapiens
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