Cloned (Comment) | Organism |
---|---|
expression in HEK-203 cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | chimeric protein in which the core kinase domain of phosphatidylinositol 4-phosphate 5-kinase 1alpha has been fused to a beta-arrestin mutant deficient in phosphatidylinositol 4,5-bisphosphate binding rescues internalization of beta2-adrenergic receptor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | beta-arrestins direct the localization of phosphatidylinositol 4-phosphate 5-kinase 1alpha and phosphatidylinositol 4,5-bisphosphate production to agonist-activated 7-transmembrane receptors, thereby regulating receptor internalization | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | beta-arrestins direct the localization of phosphatidylinositol 4-phosphate 5-kinase 1alpha and phosphatidylinositol 4,5-bisphosphate production to agonist-activated 7-transmembrane receptors, thereby regulating receptor internalization | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | following stimulation of the beta2-adrenergic receptor, beta-arrestins bind phosphatidylinositol 4-phosphate 5-kinase 1alpha. A beta-arrestin mutant deficient in phosphatidylinositol 4,5-bisphosphate binding fails to interact with phosphatidylinositol 4-phosphate 5-kinase 1alpha and is not associated with phosphatidylinositol kinase activity in vitro, and no longer internalizes beta2-adrenergic receptor | Homo sapiens |