BRENDA - Enzyme Database
show all sequences of 2.7.1.68

Activation of PI(4)P 5-kinase by small G proteins

Kanaho, Y.; Miyazaki, H.; Yamazaki, M.; Adv. Enzyme Regul. 43, 107-119 (2003)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
small G protein ARF
ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophosphatidic acid, but by competitive phosphatidylcholine, reconstitution of the recombinant either isozyme alpha, beta, or gamma with recombinant class II and III ARFs, ARF5 and ARF6, respectively, as well as myristoylated class I ARF in presence of GTPgammaS or GDP, and phosphatidic acid activates the isozymes
Mus musculus
small G protein RHO
activates the enzyme in neurits, crucial in cell shapig together with the enzyme, overview
Mus musculus
small G proteins
-
Bos taurus
small G proteins ARF
ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophosphatidic acid, but by competitive phosphatidylcholine
Homo sapiens
small G proteins ARF
ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophosphatidic acid, but by competitive phosphatidylcholine
Rattus norvegicus
Cloned(Commentary)
Commentary
Organism
functional expression in HeLa cells as GFP-fusion protein, translocation to the plasma membrane by coexpression of ARF6 upon stimulation by EGF, coexpression of ARF6 mutant N122I inhibits the membrane ruffling, overview
Homo sapiens
overexpression of mutant D266A in N1E-115 cells, expression of isozyme alpha in COS-7 cells, expression of isozyme alpha in Escherichia coli
Mus musculus
Engineering
Amino acid exchange
Commentary
Organism
D266A
site-directed mtagenesis, mutation of the putative ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate binding site, cells form extremely extended bipolar neurits even in presence of serum, failed to interfere with cell flattening and neurite extension
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
GTPgammaS shows poor or no activation of the brain cytosol enzyme but acts synergistically with phosphatidic acid
Bos taurus
phosphatidic acid
2-3fold activation of the brain cytosol enzyme, 30fold enhancement of the activation by GTPgammaS, even higher activation by addition of recombinant mouse isozyme alpha
Bos taurus
small G proteins ARF
ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophophatidic acid, but by competitive phosphatidylcholine, proteins ARF1 and ARF3, from brain cytosol, purification and identification, the 21 kDa G-proteins are activated by GTPgammaS, not by GDP, and activate themselves the PI(4)P 5-kinase
Bos taurus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Bos taurus
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Mus musculus
5829
-
Golgi apparatus
ARF recruits brain cytosol enzyme from the cytosol to the Golgi complex in an in vitro system
Bos taurus
5794
-
plasma membrane
translocation to the plasma membrane of isozyme beta is dependent on ARF6 and EGF, and is completely inhibited by the recombinant GTP-binding-deficient ARF6 mutant N122I
Homo sapiens
5886
-
plasma membrane
translocation to the plasma membrane of isozyme alpha is dependent on ARF6 and EGF
Mus musculus
5886
-
plasma membrane
translocation to the plasma membrane of isozyme alpha is dependent on ARF6 and EGF
Rattus norvegicus
5886
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Bos taurus
Mg2+
-
Rattus norvegicus
Mg2+
-
Homo sapiens
Mg2+
-
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Mus musculus
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Bos taurus
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Rattus norvegicus
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
?
additional information
Homo sapiens
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
?
-
-
-
additional information
Rattus norvegicus
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
?
-
-
-
additional information
Bos taurus
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
?
-
-
-
additional information
Mus musculus
enzyme is important in cell signaling and cell shaping, overview, the enzyme is essential for regulation of neurite modeling, ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Homo sapiens
-
3 isozymes alpha, beta, and gamma
-
Mus musculus
-
3 isozymes alpha, beta, and gamma
-
Rattus norvegicus
-
3 isozymes alpha, beta, and gamma
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Bos taurus
-
fibroblast
-
Mus musculus
-
N1E-115 cell
neuroblastoma cell
Mus musculus
-
neuroblastoma cell
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Mus musculus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Homo sapiens
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Rattus norvegicus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Bos taurus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Mus musculus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Bos taurus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Homo sapiens
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Rattus norvegicus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
-
?
additional information
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
660641
Homo sapiens
?
-
-
-
-
additional information
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
660641
Rattus norvegicus
?
-
-
-
-
additional information
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
660641
Bos taurus
?
-
-
-
-
additional information
enzyme is important in cell signaling and cell shaping, overview, the enzyme is essential for regulation of neurite modeling, ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
660641
Mus musculus
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
More
the enzyme possesses a central socalled kinase core domain containing the activation loop which is responsible for substrate specificity and subcellular targeting of the enzyme
Bos taurus
More
the enzyme possesses a central so-called kinase core domain containing the activation loop which is responsible for substrate specificity and subcellular targeting of the enzyme
Homo sapiens
More
the enzyme possesses a central so-called kinase core domain containing the activation loop which is responsible for substrate specificity and subcellular targeting of the enzyme
Mus musculus
More
the enzyme possesses a central socalled kinase core domain containing the activation loop which is responsible for substrate specificity and subcellular targeting of the enzyme
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Bos taurus
ATP
-
Rattus norvegicus
ATP
-
Homo sapiens
ATP
-
Mus musculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
small G protein ARF
ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophosphatidic acid, but by competitive phosphatidylcholine, reconstitution of the recombinant either isozyme alpha, beta, or gamma with recombinant class II and III ARFs, ARF5 and ARF6, respectively, as well as myristoylated class I ARF in presence of GTPgammaS or GDP, and phosphatidic acid activates the isozymes
Mus musculus
small G protein RHO
activates the enzyme in neurits, crucial in cell shapig together with the enzyme, overview
Mus musculus
small G proteins
-
Bos taurus
small G proteins ARF
ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophosphatidic acid, but by competitive phosphatidylcholine
Homo sapiens
small G proteins ARF
ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophosphatidic acid, but by competitive phosphatidylcholine
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
functional expression in HeLa cells as GFP-fusion protein, translocation to the plasma membrane by coexpression of ARF6 upon stimulation by EGF, coexpression of ARF6 mutant N122I inhibits the membrane ruffling, overview
Homo sapiens
overexpression of mutant D266A in N1E-115 cells, expression of isozyme alpha in COS-7 cells, expression of isozyme alpha in Escherichia coli
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Bos taurus
ATP
-
Rattus norvegicus
ATP
-
Homo sapiens
ATP
-
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
D266A
site-directed mtagenesis, mutation of the putative ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate binding site, cells form extremely extended bipolar neurits even in presence of serum, failed to interfere with cell flattening and neurite extension
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
GTPgammaS shows poor or no activation of the brain cytosol enzyme but acts synergistically with phosphatidic acid
Bos taurus
phosphatidic acid
2-3fold activation of the brain cytosol enzyme, 30fold enhancement of the activation by GTPgammaS, even higher activation by addition of recombinant mouse isozyme alpha
Bos taurus
small G proteins ARF
ARF activation absolutely requires the presence of phosphatidic acid, which cannot be substituted by phosphatidylserine, phosphatidylethanolamine, or lysophophatidic acid, but by competitive phosphatidylcholine, proteins ARF1 and ARF3, from brain cytosol, purification and identification, the 21 kDa G-proteins are activated by GTPgammaS, not by GDP, and activate themselves the PI(4)P 5-kinase
Bos taurus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Bos taurus
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Mus musculus
5829
-
Golgi apparatus
ARF recruits brain cytosol enzyme from the cytosol to the Golgi complex in an in vitro system
Bos taurus
5794
-
plasma membrane
translocation to the plasma membrane of isozyme beta is dependent on ARF6 and EGF, and is completely inhibited by the recombinant GTP-binding-deficient ARF6 mutant N122I
Homo sapiens
5886
-
plasma membrane
translocation to the plasma membrane of isozyme alpha is dependent on ARF6 and EGF
Mus musculus
5886
-
plasma membrane
translocation to the plasma membrane of isozyme alpha is dependent on ARF6 and EGF
Rattus norvegicus
5886
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Bos taurus
Mg2+
-
Rattus norvegicus
Mg2+
-
Homo sapiens
Mg2+
-
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Mus musculus
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Bos taurus
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Rattus norvegicus
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
?
additional information
Homo sapiens
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
?
-
-
-
additional information
Rattus norvegicus
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
?
-
-
-
additional information
Bos taurus
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
?
-
-
-
additional information
Mus musculus
enzyme is important in cell signaling and cell shaping, overview, the enzyme is essential for regulation of neurite modeling, ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Bos taurus
-
fibroblast
-
Mus musculus
-
N1E-115 cell
neuroblastoma cell
Mus musculus
-
neuroblastoma cell
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Mus musculus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Homo sapiens
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Rattus norvegicus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Bos taurus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Mus musculus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Bos taurus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiologic functions, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Homo sapiens
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
660641
Rattus norvegicus
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate has several important physiological functions, overview
-
-
?
additional information
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
660641
Homo sapiens
?
-
-
-
-
additional information
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
660641
Rattus norvegicus
?
-
-
-
-
additional information
ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
660641
Bos taurus
?
-
-
-
-
additional information
enzyme is important in cell signaling and cell shaping, overview, the enzyme is essential for regulation of neurite modeling, ARF6-dependent enzyme activation plays an important role in signal transduction of membrane ruffling formation through 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
660641
Mus musculus
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
More
the enzyme possesses a central socalled kinase core domain containing the activation loop which is responsible for substrate specificity and subcellular targeting of the enzyme
Bos taurus
More
the enzyme possesses a central so-called kinase core domain containing the activation loop which is responsible for substrate specificity and subcellular targeting of the enzyme
Homo sapiens
More
the enzyme possesses a central so-called kinase core domain containing the activation loop which is responsible for substrate specificity and subcellular targeting of the enzyme
Mus musculus
More
the enzyme possesses a central socalled kinase core domain containing the activation loop which is responsible for substrate specificity and subcellular targeting of the enzyme
Rattus norvegicus
Other publictions for EC 2.7.1.68
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738288
Porciello
Phosphatidylinositol 4-phospha ...
Homo sapiens
Front. Immunol.
7
186
2016
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
738794
Kallikourdis
Phosphatidylinositol 4-phospha ...
Homo sapiens
J. Immunol.
196
1955-1963
2016
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
739370
Ugalde
Phosphatidylinositol 4-phospha ...
Arabidopsis thaliana
Plant Sci.
250
10-19
2016
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
738199
Lacalle
Type I phosphatidylinositol 4- ...
Homo sapiens
FASEB J.
29
2371-2385
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
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3
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1
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Type Igamma PIP kinase is a no ...
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672374
Perez-Mansilla
The differential regulation of ...
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1
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Halstead
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673833
Cabezas
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Stimulation of phosphatidylino ...
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3
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672961
Akiyama
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2
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Disturbance of sphingolipid bi ...
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1
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Deng
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1
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1
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Powner
Phospholipase D2 stimulates in ...
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1
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1
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Kisseleva
The LIM protein Ajuba regulate ...
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1
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1
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1
1
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1
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1
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1
-
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1
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676789
Gong
Phosphatidylinositol phosphate ...
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Proc. Natl. Acad. Sci. USA
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2
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1
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1
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1
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2
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1
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660875
Arioka
Dibasic amino acid residues at ...
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2004
2
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1
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1
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1
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-
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2
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-
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1
-
-
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2
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1
1
-
1
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-
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1
1
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1
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-
-
-
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2
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-
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-
-
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660965
Giudici
A novel neuronal-specific spli ...
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1
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2
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4
-
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2
1
1
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-
-
1
-
-
1
-
-
-
-
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1
1
-
2
-
-
-
-
-
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2
1
2
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1
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4
-
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2
1
1
-
-
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1
-
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661660
Oude Weernink
Regulation and cellular roles ...
Candida albicans, Homo sapiens, Mus musculus, Saccharomyces cerevisiae, Schizosaccharomyces pombe
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15
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5
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6
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15
3
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5
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15
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5
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-
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3
5
4
10
-
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5
-
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6
-
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15
3
-
-
-
-
-
-
-
-
-
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-
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660641
Kanaho
Activation of PI(4)P 5-kinase ...
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
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43
107-119
2003
5
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2
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1
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3
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8
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4
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4
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12
4
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-
-
-
-
-
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4
-
-
-
5
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2
4
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1
-
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3
-
-
8
4
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8
-
-
-
-
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4
-
-
12
4
-
-
-
-
-
-
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-
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662494
Padron
Phosphatidylinositol phosphate ...
Mus musculus
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693-701
2003
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1
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-
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2
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-
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1
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-
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1
1
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-
-
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-
-
-
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1
-
1
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-
-
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2
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662546
Wong
Arf6 and phosphoinositol-4-pho ...
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603-614
2003
1
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3
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1
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1
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1
1
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1
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2
1
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2
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641839
Galiano
Overexpression of murine phosp ...
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2
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641847
Coppolino
Inhibition of phosphatidylinos ...
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1
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641848
Yamazaki
Phosphatidylinositol 4-phospha ...
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1
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641851
Hairfield
Phosphatidylinositol-4-phospha ...
Candida albicans
Microbiology
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1
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641856
van Horck
Essential role of type I(alpha ...
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641846
Barbieri
Phosphatidylinositol-4-phospha ...
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641852
Wenk
PIP kinase Ig is the major PI( ...
Rattus norvegicus
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641855
Park
Phosphatidylinositol 4-phospha ...
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Jones
Type I phosphatidylinositol 4- ...
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1
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641853
Tolias
Type Ialpha phosphatidylinosit ...
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2000
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641854
Oude Weernink
Stimulation of phosphatidylino ...
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641844
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Regulation of phosphatidylinos ...
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1
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2
1
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641843
Homma
Phosphatidylinositol-4-phospha ...
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641845
Mikami
A gene encoding phosphatidylin ...
Arabidopsis thaliana
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1998
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1
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641840
Zhang
Phosphatidylinositol-4-phospha ...
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8
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3
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641841
Cutler
STT4 is an essential phosphati ...
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1
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641842
Loijens
Type I phosphatidylinositol-4- ...
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J. Biol. Chem.
271
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1
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8
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2
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641849
Kwok
Phosphatidylinositol phosphate ...
Ovis aries
Prep. Biochem. Biotechnol.
26
1-19
1996
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1
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1
1
2
1
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641771
Moritz
Phosphatidylinositol 4-kinase ...
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Methods Enzymol.
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202-211
1992
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1
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1
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2
1
1
1
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641825
Bazenet
Phosphatidylinositol-4-phospha ...
Homo sapiens
Methods Enzymol.
209
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1992
2
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7
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2
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1
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641835
Moritz
Phosphatidic acid is a specifi ...
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2
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641823
Moritz
Purification of a phosphatidyl ...
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1
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1
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2
1
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1
1
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641831
Urumow
Purification and partial chara ...
Rattus norvegicus
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1
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2
1
2
1
3
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1
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1
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1
1
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2
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641827
Kato
Activation of phosphatidylinos ...
Saccharomyces cerevisiae
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1989
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2
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641832
Husebye
Purification and kinetic prope ...
Bos taurus
Biochim. Biophys. Acta
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250-257
1989
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3
2
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1
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1
1
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2
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3
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2
1
2
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1
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1
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1
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641834
Ling
Characterization and purificat ...
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264
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2
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2
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1
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1
1
2
1
1
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-
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641772
Sommarin
-
Phosphatidylinositol and phosp ...
Triticum aestivum
Biochim. Biophys. Acta
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268-278
1988
1
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2
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2
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1
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3
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641828
Lundberg
Activation of phosphatidylinos ...
Rattus norvegicus
Biochim. Biophys. Acta
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1-7
1987
1
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1
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1
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641824
Smith
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The phosphatidylinositol 4-pho ...
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1986
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2
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2
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641829
Cochet
Catalytic properties of a puri ...
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1986
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1
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1
1
1
2
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641830
Lundberg
Phosphatidylinositol-4-phospha ...
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Eur. J. Biochem.
161
257-262
1986
3
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1
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1
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1
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3
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1
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1
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1
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1
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1
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641826
Van Rooijen
Inhibition of phosphatidylinos ...
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Biochem. Biophys. Res. Commun.
126
150-155
1985
-
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1
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1
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1
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1
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1
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641833
Van Dongen
Purification and partial chara ...
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223
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2
1
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1
1
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1
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2
1
1
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1
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2
1
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1
1
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1
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641773
Cooper
Phosphatidylinositol kinase an ...
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6
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1
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1
1
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6
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1
5
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2
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1
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1
1
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641822
Kai
The diphosphoinositide kinase ...
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1
1
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1
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7
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1
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4
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1
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1
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1
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1
1
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