Literature summary for 2.7.1.68 extracted from

Yamazaki, M.; Miyazaki, H.; Watanabe, H.; Sasaki, T.; Maehama, T.; Frohman, M.A.; Kanaho, Y.
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling (2002), J. Biol. Chem., 277, 17226-17230.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	Mus musculus	PIP-5kina-alpha functions as a downstream effector for RhoA/ROCK to couple lysophosphatidic acid signaling to neurite retraction presumably through its product phosphatidylinositol 4,5-bisphosphate	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
N1E-115 cell	neuroblastoma	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	Mus musculus	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	PIP-5kina-alpha functions as a downstream effector for RhoA/ROCK to couple lysophosphatidic acid signaling to neurite retraction presumably through its product phosphatidylinositol 4,5-bisphosphate	Mus musculus	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?

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Release 2023.1 (January 2023)