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Literature summary for 2.7.1.67 extracted from

  • Lopez-Haber, C.; Levin-Konigsberg, R.; Zhu, Y.; Bi-Karchin, J.; Balla, T.; Grinstein, S.; Marks, M.S.; Mantegazza, A.R.
    Phosphatidylinositol-4-kinase IIalpha licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells (2020), Proc. Natl. Acad. Sci. USA, 117, 28251-28262 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.67

Localization

Localization Comment Organism GeneOntology No. Textmining
phagosome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol Mus musculus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Mus musculus
-
dendritic cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol-4-kinase IIalpha
-
 Mus musculus
PI4KIIalpha
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockdown of isoform PI4KIIalpha -but not PI4KIIbeta - impairs toll-interleukin 1 receptor domain-containing adaptor protein and toll-like receptor 4 localization to phagosomes, reduces proinflammatory cytokine secretion, abolishes phagosomal tubule formation, and impairs major histocompatibility complex II presentation Mus musculus
physiological function isoform PI4KIIalpha is an essential regulator of phagosomal toll-like receptor signaling in dendritic cells by ensuring optimal toll-interleukin 1 receptor domain-containing adaptor protein recruitment to phagosomes Mus musculus