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Literature summary for 2.7.1.67 extracted from

  • Gimenez, A.M.; Gesumaria, M.C.; Schoijet, A.C.; Alonso, G.D.; Flawia, M.M.; Racagni, G.E.; Machado, E.E.
    Phosphatidylinositol kinase activities in Trypanosoma cruzi epimastigotes (2015), Mol. Biochem. Parasitol., 203, 14-24.
    View publication on PubMed
Search for more literature for 2.7.1.67

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 60% increase of activity at 1 mM Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ inhibitory at millimolar concentrations Trypanosoma cruzi
deoxycholate complete inhibition at 0.5 mM Trypanosoma cruzi
Mg2+ inhibitory at concentrations above 5 mM Trypanosoma cruzi
additional information not affected by adenosine Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Trypanosoma cruzi 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ the optimum concentration is 3 mM Trypanosoma cruzi
additional information not affected by micromolar Ca2+ concentrations Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol Trypanosoma cruzi
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epimastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Trypanosoma cruzi ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 4 kinase
-
 Trypanosoma cruzi
PI4K
-
 Trypanosoma cruzi