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Literature summary for 2.7.1.67 extracted from
- Coordination of Golgi functions by phosphatidylinositol 4-kinases (2011), Trends Cell Biol., 21, 113-121.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | at Golgi-endoplasmic reticulum contact points | Saccharomyces cerevisiae | 5783 | - |
| Golgi apparatus | at Golgi-endoplasmic reticulum contact points | Saccharomyces cerevisiae | 5794 | - |
| Golgi apparatus | principal PI4Ks of the Golgi apparatus are PI4KIIalpha and PI4KIIIbeta | Homo sapiens | 5794 | - |
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | - |
Saccharomyces cerevisiae | 16020 | - |
| nucleus | PI4KIIIbeta shuttles through the nucleus | Homo sapiens | 5634 | - |
| nucleus | Pik1 shuttles through the nucleus. Nuclear accumulation of Pik1 is promoted by nutrient, e.g. glucose, deprivation, a condition that also results in the release of PI4K effectors from Golgi membranes and slowing of the rate of secretion | Saccharomyces cerevisiae | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
| Mg2+ | required | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | Saccharomyces cerevisiae | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | yeast Pik1 is phosphorylated by a protein kinase, phosphorylation promotes dissociation of Pik1 from Golgi membranes and association with the 14-3-3 proteins Bmh1 and Bmh2 in the cytosol | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Saccharomyces cerevisiae | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphatidylinositol 4-kinase | - |
Homo sapiens |
| phosphatidylinositol 4-kinase | - |
Saccharomyces cerevisiae |
| PI4K | - |
Homo sapiens |
| PI4K | - |
Saccharomyces cerevisiae |
| Pik1 | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Saccharomyces cerevisiae | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | regulation of the Golgi system and 1-phosphatidyl-1D-myo-inositol 4-phosphate levels involving the enzyme, overview | Homo sapiens |
| metabolism | regulation of the Golgi system and 1-phosphatidyl-1D-myo-inositol 4-phosphate levels involving the enzyme, overview | Saccharomyces cerevisiae |
| additional information | nuclear accumulation of Pik1 is promoted by nutrient, e.g. glucose, deprivation, a condition that also results in the release of PI4K effectors from Golgi membranes and slowing of the rate of secretion | Saccharomyces cerevisiae |
| physiological function | phosphatidylinositol 4-kinases regulate vesicle mediate export from the Golgi apparatus via phosphatidylinositol 4-phosphate binding effector proteins that control vesicle budding reactions and regulate membrane dynamics. Function of phosphatidylinositol 4-phosphate at the Golgi Membrane biogenesis and lipid homeostasis | Homo sapiens |
| physiological function | phosphatidylinositol 4-kinases regulate vesicle mediate export from the Golgi apparatus via phosphatidylinositol 4-phosphate binding effector proteins that control vesicle budding reactions and regulate membrane dynamics. Function of phosphatidylinositol 4-phosphate at the Golgi Membrane biogenesis and lipid homeostasis | Saccharomyces cerevisiae |
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