Activating Compound | Comment | Organism | Structure |
---|---|---|---|
25-hydroxycholesterol | activates Golgi/endosome-associated PI4K activity, PI4K activation by 25-hydroxycholesterol is dependent on oxysterol binding protein, overview | Cricetulus griseus | |
oxysterol binding protein | activates Golgi/endosome-associated PI4K activity, required for PI4K activation by 25-hydroxycholesterol, overview | Cricetulus griseus |
Cloned (Comment) | Organism |
---|---|
isozymes PI4KIIalpha or PI4KIIIbeta | Cricetulus griseus |
transient expression of GFP-PI4KIIalpha in CHO cells, the tagged enzyme is present in perinuclear vesicles in control and 25-hydroxycholesterol-treated cells, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cholesterol | cholesterol sensitivity of PI4KIIalpha | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Cricetulus griseus | 5768 | - |
endosome | - |
Homo sapiens | 5768 | - |
Golgi apparatus | - |
Cricetulus griseus | 5794 | - |
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Golgi membrane | - |
Cricetulus griseus | 139 | - |
Golgi membrane | - |
Homo sapiens | 139 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Cricetulus griseus | |
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | Cricetulus griseus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | - |
Cricetulus griseus | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Cricetulus griseus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 4-kinase IIalpha | - |
Cricetulus griseus |
phosphatidylinositol 4-kinase IIalpha | - |
Homo sapiens |
PI4K | - |
Cricetulus griseus |
PI4K | - |
Homo sapiens |
PI4KIIalpha | - |
Cricetulus griseus |
PI4KIIalpha | - |
Homo sapiens |
PtdIns 4-kinase | - |
Cricetulus griseus |
PtdIns 4-kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Cricetulus griseus | |
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | inactivation of isozyme PI4KIIalpha by expression of siRNAs in HeLa cells | additional information |
Cricetulus griseus | inactivation of isozymes PI4KIIalpha and PI4KIIabeta by expression of siRNAs in CHO cells and by RNAi | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | phosphatidylinositol 4-kinase IIalpha is required for oxysterol binding protein-dependent activation of sphingomyelin synthesis in the Golgi apparatus, overview | Cricetulus griseus |
physiological function | phosphatidylinositol 4-kinase IIalpha is required for oxysterol binding protein-dependent activation of sphingomyelin synthesis in the Golgi apparatus, overview | Homo sapiens |