Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | elevated phosphatidylinositol kinase activity in Rous sarcoma virus-transformed and in Eppstein Barr virus-infected cells | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | type II phosphatidylinositol 4-kinases are promising targets for therapeutic intervention against viral infections, detailed overview | Homo sapiens |
pharmacology | type II phosphatidylinositol 4-kinases are promising targets for therapeutic intervention against viral infections, detailed overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-1-(isopropylsulfonyl)-6-benzimidazole phenylketone oxime | i.e. enviroxime, inhibitor of the in vitro replication of rhinoviruses and enteroviruses, inhibits hepatitis C virus subgenomic replicon replication | Homo sapiens | |
Cpd 6 | - |
Homo sapiens | |
N-(5-[4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methyl-1,3-thiazol-2-yl)acetamide | i.e. PIK93, a phenylthiazole | Homo sapiens | |
tert-butyl N-[[8-(2-chlorophenyl)-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl]carbamoyl]-beta-alaninate | i.e. Inhibitor A | Homo sapiens | |
[5-(4-[[4-(morpholin-4-yl)phenyl]amino]quinazolin-6-yl)furan-2-yl]methanol | i.e. AL-9 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | type II PI 4-kinase enzymes | Homo sapiens | 16020 | - |
plasma membrane | type II PI 4-kinase enzymes | Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
additional information | Homo sapiens | the 3A protein from multiple picornaviruses, ncluding Aichi virus, bovine kobuvirus, CVB, HRV14, poliovirus, associates with isozyme PI4KIIIbeta and ACBD3 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
additional information | the 3A protein from multiple picornaviruses, ncluding Aichi virus, bovine kobuvirus, CVB, HRV14, poliovirus, associates with isozyme PI4KIIIbeta and ACBD3 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 4-kinase | - |
Homo sapiens |
phosphatidylinositol 4-kinase IIIbeta | - |
Homo sapiens |
PI4KIIIbeta | - |
Homo sapiens |
type II PI 4-kinase enzyme | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000019 | - |
isozyme PI4KIIIbeta, pH and temperature not specified in the publication | Homo sapiens | N-(5-[4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methyl-1,3-thiazol-2-yl)acetamide | |
0.000024 | - |
isozyme PI4KIIIbeta, pH and temperature not specified in the publication | Homo sapiens | Cpd 6 | |
0.00012 | - |
isozyme PI4KIIIbeta, pH and temperature not specified in the publication | Homo sapiens | 2-amino-1-(isopropylsulfonyl)-6-benzimidazole phenylketone oxime | |
0.00045 | - |
isozyme PI4KIIIalpha, pH and temperature not specified in the publication | Homo sapiens | tert-butyl N-[[8-(2-chlorophenyl)-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl]carbamoyl]-beta-alaninate | |
0.00057 | - |
isozyme PI4KIIIalpha, pH 7.5, 22°C | Homo sapiens | [5-(4-[[4-(morpholin-4-yl)phenyl]amino]quinazolin-6-yl)furan-2-yl]methanol | |
0.0011 | - |
isozyme PI4KIIIalpha, pH and temperature not specified in the publication | Homo sapiens | N-(5-[4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methyl-1,3-thiazol-2-yl)acetamide | |
0.0014 | - |
isozyme PI4KIIIalpha, pH and temperature not specified in the publication | Homo sapiens | 2-amino-1-(isopropylsulfonyl)-6-benzimidazole phenylketone oxime | |
0.0031 | - |
isozyme PI4KIIIbeta, pH 7.5, 22°C | Homo sapiens | [5-(4-[[4-(morpholin-4-yl)phenyl]amino]quinazolin-6-yl)furan-2-yl]methanol |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing of isozyme PI4KIIIbeta, but not ofisozyme PI4KIIIa strongly inhibits SARS CoV spike-mediated entry | Homo sapiens |
physiological function | PI4KIIIalpha is a host factor for hepatitis C virus. Isozyme PI4KIIIbet is involved in the entry of SARS coronavirus. PI4KIIIbeta is not required for virus binding and internalization, but plays a role at, or before, virus fusion with the late endosomes. Modes of recruitment of PI4KIIIs to the replication complexes of hepattis C virus, enteroviruses, and the Aichi virus, overview | Homo sapiens |