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Literature summary for 2.7.1.67 extracted from

  • Balla, A.; Balla, T.
    Phosphatidylinositol 4-kinases: old enzymes with emerging functions (2006), Trends Cell Biol., 16, 351-361.
    View publication on PubMed
Search for more literature for 2.7.1.67

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100
-
 Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
adenosine inhibits in the millimolar range Saccharomyces cerevisiae
Ca2+
-
 Saccharomyces cerevisiae
Ly-294002 IC50: 0.05-0.1 mM; IC50: 0.1 mM Saccharomyces cerevisiae
additional information insensitive to wortmannin and LY-294002 Saccharomyces cerevisiae
Phenylarsine oxide IC50: 0.001-0.005 mM; IC50: 0.03 mM; IC50: above 0.1 mM Saccharomyces cerevisiae
Wortmannin IC50: 0.05-0.3 mM; IC50: 50-300 nM Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01 0.05 ATP
-
 Saccharomyces cerevisiae
0.02 0.06 1-phosphatidyl-1D-myo-inositol
-
 Saccharomyces cerevisiae
0.1
-
 1-phosphatidyl-1D-myo-inositol
-
 Saccharomyces cerevisiae
0.4
-
 ATP
-
 Saccharomyces cerevisiae
0.7
-
 ATP
-
 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Saccharomyces cerevisiae 5794
-
plasma membrane
-
 Saccharomyces cerevisiae 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no direct effect by Ca2+ Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
 calculated from amino acid sequence Saccharomyces cerevisiae
55000
-
 calculated from amino acid sequence Saccharomyces cerevisiae
92000
-
 calculated from amino acid sequence Saccharomyces cerevisiae
230000
-
 calculated from amino acid sequence Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Saccharomyces cerevisiae ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 r

Synonyms

Synonyms Comment Organism
56 kDa type II PtdIns 4-kinase
-
 Saccharomyces cerevisiae
Lsb6p
-
 Saccharomyces cerevisiae
phosphatidylinositol 4-kinase
-
 Saccharomyces cerevisiae
Pik1p
-
 Saccharomyces cerevisiae
PIK230
-
 Saccharomyces cerevisiae
Pik2p
-
 Saccharomyces cerevisiae
Pik4ca
-
 Saccharomyces cerevisiae
PIK4IIalpha
-
 Saccharomyces cerevisiae
PIK4IIbeta
-
 Saccharomyces cerevisiae
PIK4IIIalpha
-
 Saccharomyces cerevisiae
PIK4IIIbeta
-
 Saccharomyces cerevisiae
PIK55
-
 Saccharomyces cerevisiae
PtdIns 4-kinase
-
 Saccharomyces cerevisiae
PtdIns 4-kinase beta
-
 Saccharomyces cerevisiae
Stt4p
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01 0.07 adenosine
-
 Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00005 0.0003 IC50: 50-300 nM Saccharomyces cerevisiae Wortmannin
0.001 0.005 IC50: 0.001-0.005 mM Saccharomyces cerevisiae Phenylarsine oxide
0.03
-
 IC50: 0.03 mM Saccharomyces cerevisiae Phenylarsine oxide
0.05 0.1 IC50: 0.05-0.1 mM Saccharomyces cerevisiae Ly-294002
0.05 0.3 IC50: 0.05-0.3 mM Saccharomyces cerevisiae Wortmannin
0.1
-
 IC50: 0.1 mM Saccharomyces cerevisiae Ly-294002
0.1
-
 IC50: above 0.1 mM Saccharomyces cerevisiae Phenylarsine oxide