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Literature summary for 2.7.1.67 extracted from

  • Guo, J.; Wenk, M.R.; Pellegrini, L.; Onofri, F.; Benfenati, F.; De Camilli, P.
    Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles (2003), Proc. Natl. Acad. Sci. USA, 100, 3995-4000.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol Rattus norvegicus generation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the enzyme on synaptic vesicles may be the first step in the resynthesis of phosphatidylinositol 4,5-bisphosphate ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Purification (Commentary)

Purification (Comment) Organism
enzyme type IIalpha Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain the type IIalpha enzyme is concentrated both at the synapse and in the region of the Golgi complex in neuronal perikarya Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
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Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
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ATP + 1-phosphatidyl-1D-myo-inositol generation of 1-phosphatidyl-1D-myo-inositol 4-phosphate by the enzyme on synaptic vesicles may be the first step in the resynthesis of phosphatidylinositol 4,5-bisphosphate Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
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