Any feedback?
Literature summary for 2.7.1.67 extracted from
- Identification and characterization of the phosphatidylinositol kinase in membranes of murine T lymphocytes (1986), J. Immunol., 137, 971-976.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | competitive inhibitor of Mg2+ | Mus musculus |  |
| phosphatidylinositol 4,5-bisphosphate | - |
Mus musculus | |
| phosphatidylinositol 4-phosphate | - |
Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
ATP | pH 7.1, 25°C | Mus musculus | |
| 0.62 | - |
GTP | pH 7.1, 25°C | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | integral membrane protein | Mus musculus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | dependent on Mg2+ or Mn2+. Km for Mg2+ is about 5 mM | Mus musculus | |
| Mn2+ | dependent on Mg2+ or Mn2+ | Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
gel filtration | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| T-lymphocyte | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| GTP + 1-phosphatidyl-1D-myo-inositol | - |
Mus musculus | GDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
enzyme is stable | Mus musculus |
| 33 | - |
3 min, 50% inactivation | Mus musculus |
| 56 | - |
cell lysate, 5 min, virtually all activity is lost | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | - |
Mus musculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 12 | - |
Ca2+ | pH 7.1, 25°C | Mus musculus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
