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Literature summary for 2.7.1.67 extracted from

  • Endemann, G.; Dunn, S.N.; Cantley, L.C.
    Bovine brain contains two types of phosphatidylinositol kinase (1987), Biochemistry, 26, 6845-6852.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 type 2 and type 3 enzyme are maximally active in 0.1-0.5% Triton X-100 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
adenosine
-
Bos taurus
ADP
-
Bos taurus
AMP
-
Bos taurus
phosphatidylcholine inhibits type 3 kinase more strongly than type 2 kinase Bos taurus
phosphatidylinositol 4-phosphate
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.017
-
phosphatidylinositol room temperature, enzyme type 2 Bos taurus
0.054
-
ATP room temperature, enzyme type 2 Bos taurus
0.127
-
phosphatidylinositol room temperature, enzyme type 3 Bos taurus
0.742
-
ATP room temperature, enzyme type 3 Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Km for type 2 kinase is 0.6 mM, Km for type 3 kinase is 2.6 mM Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
enzyme type 2, sucrose density gradient centrifugation Bos taurus
230000
-
enzyme type 3, sucrose density gradient centrifugation Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
Bos taurus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
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Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.018
-
adenosine room temperature, enzyme type 2 Bos taurus
0.027
-
AMP room temperature, enzyme type 2 Bos taurus
0.235
-
phosphatidylinositol 4-phosphate room temperature Bos taurus
0.24
-
AMP room temperature, enzyme type 2 Bos taurus
0.57
-
ADP room temperature, enzyme type 3 Bos taurus
0.774
-
phosphatidylinositol 4-phosphate room temperature Bos taurus
1.52
-
adenosine room temperature, enzyme type 3 Bos taurus
2.82
-
AMP room temperature, enzyme type 3 Bos taurus