Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Triton X-100 | type 2 and type 3 enzyme are maximally active in 0.1-0.5% Triton X-100 | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine | - |
Bos taurus | |
ADP | - |
Bos taurus | |
AMP | - |
Bos taurus | |
phosphatidylcholine | inhibits type 3 kinase more strongly than type 2 kinase | Bos taurus | |
phosphatidylinositol 4-phosphate | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
phosphatidylinositol | room temperature, enzyme type 2 | Bos taurus | |
0.054 | - |
ATP | room temperature, enzyme type 2 | Bos taurus | |
0.127 | - |
phosphatidylinositol | room temperature, enzyme type 3 | Bos taurus | |
0.742 | - |
ATP | room temperature, enzyme type 3 | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | Km for type 2 kinase is 0.6 mM, Km for type 3 kinase is 2.6 mM | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
enzyme type 2, sucrose density gradient centrifugation | Bos taurus |
230000 | - |
enzyme type 3, sucrose density gradient centrifugation | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Bos taurus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
adenosine | room temperature, enzyme type 2 | Bos taurus | |
0.027 | - |
AMP | room temperature, enzyme type 2 | Bos taurus | |
0.235 | - |
phosphatidylinositol 4-phosphate | room temperature | Bos taurus | |
0.24 | - |
AMP | room temperature, enzyme type 2 | Bos taurus | |
0.57 | - |
ADP | room temperature, enzyme type 3 | Bos taurus | |
0.774 | - |
phosphatidylinositol 4-phosphate | room temperature | Bos taurus | |
1.52 | - |
adenosine | room temperature, enzyme type 3 | Bos taurus | |
2.82 | - |
AMP | room temperature, enzyme type 3 | Bos taurus |