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Literature summary for 2.7.1.67 extracted from

  • Kai, M.; White, G.L.; Hawthorne, J.N.
    The phosphatidylinositol kinase of rat brain (1966), Biochem. J., 101, 328-337.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.67

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol enhances activity Rattus norvegicus
3-Mercaptopropionic acid enhances activity Rattus norvegicus
cetyltrimethyl ammonium bromide weak stimulation Rattus norvegicus
Cutsum stimulates Rattus norvegicus
EDTA 2 mM, marked stimulation, even in presence of 30 mM Mg2+ Rattus norvegicus
GSH enhances activity Rattus norvegicus
additional information activity of the enzyme is dependent on SH groups Rattus norvegicus
sodium deoxycholate stimulates Rattus norvegicus
sodium taurocholate weak stimulation Rattus norvegicus
Triton X-100 stimulates Rattus norvegicus
Tween-20 weak stimulation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
 Rattus norvegicus
Cu2+ 0.25 mM CuCl2, complete inhibition Rattus norvegicus
F-
-
 Rattus norvegicus
K+
-
 Rattus norvegicus
Na+
-
 Rattus norvegicus
NaF 70% inhibition at 1 mM, complete inhibition at 10 mM Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ enzyme is activated by Mn2+ or Mg2+ Rattus norvegicus
Mn2+ enzyme is activated by Mg2+ or Mn2+ Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-20°C, brain homogenate in 0.32 M sucrose, stable for up to 6 d Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?