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Literature summary for 2.7.1.59 extracted from

  • Gindzienski, A.; Glowacka, D.; Zwierz, K.
    Purification and properties of N-acetylglucosamine kinase from human gastric mucosa (1974), Eur. J. Biochem., 43, 155-160.
    View publication on PubMed

General Stability

General Stability Organism
unstable to dialysis and gel filtration, 0.013 mM substrate protects against inactivation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
p-chloromercuribenzoate irreversible Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
N-acetyl-D-glucosamine 37°C, pH 8.0 Homo sapiens
1.8
-
ATP 37°C, pH 8.0 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ can partially replace Mg2+ in activation Homo sapiens
Mg2+ required Homo sapiens
Mn2+ can partially replace Mg2+ in activation Homo sapiens
additional information slight activities with Ni2+, Zn2+, Cu2+ Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
77000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N-acetyl-D-glucosamine Homo sapiens part of glycoprotein synthesis pathway ADP + N-acetyl-D-glucosamine 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
gastric mucosa
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.28
-
purified enzyme, 37°C, pH 8.0 Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, stable for at least 6 months Homo sapiens
4°C, stable for at least 3 days Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N-acetyl-D-glucosamine
-
Homo sapiens ADP + N-acetyl-D-glucosamine 6-phosphate
-
?
ATP + N-acetyl-D-glucosamine part of glycoprotein synthesis pathway Homo sapiens ADP + N-acetyl-D-glucosamine 6-phosphate
-
?
ATP + N-acetyl-D-mannosamine roughly 50% of activity Homo sapiens ADP + N-acetyl-D-mannosamine 6-phosphate
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
84% loss of activity within 2 min, no protection with added substrate Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8 8
-
Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
5
-
50% loss of activity within 2 min, no protection with added substrate Homo sapiens