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Literature summary for 2.7.1.48 extracted from

  • Balestri, F.; Barsotti, C.; Lutzemberger, L.; Camici, M.; Ipata, P.L.
    Key role of uridine kinase and uridine phosphorylase in the homeostatic regulation of purine and pyrimidine salvage in brain (2007), Neurochem. Int., 51, 517-523.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus uridine kinase and uridine phosphorylase are involved in the homeostatic regulation of purine and pyrimidine metabolism in brain. At relatively low UTP and CTP level, uptaken uridine is mainly anabolized to uridine nucleotides. At relatively high UTP and CTP levels, the inhibition of uridine kinase channels uridine towards phosphorolysis, resulting in 5-phosphoribosyl-1-bisphosphate used for purine salvage synthesis ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + uridine
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 Rattus norvegicus ADP + UMP
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 ?
additional information uridine kinase and uridine phosphorylase are involved in the homeostatic regulation of purine and pyrimidine metabolism in brain. At relatively low UTP and CTP level, uptaken uridine is mainly anabolized to uridine nucleotides. At relatively high UTP and CTP levels, the inhibition of uridine kinase channels uridine towards phosphorolysis, resulting in 5-phosphoribosyl-1-bisphosphate used for purine salvage synthesis Rattus norvegicus ?
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 ?

Cofactor

Cofactor Comment Organism Structure
ATP
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 Rattus norvegicus