Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.45 extracted from

  • Kouril, T.; Wieloch, P.; Reimann, J.; Wagner, M.; Zaparty, M.; Albers, S.V.; Schomburg, D.; Ruoff, P.; Siebers, B.
    Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic crenarchaeon Sulfolobus solfataricus P2 (2013), FEBS J., 280, 1126-1138.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining

General Information

General Information Comment Organism
malfunction deletion of the semiphosphorylative Entner-Doudoroff pathway key enzyme 2-keto-3-deoxygluconate kinase in Sulfolobus solfataricus PBL2025 results in a similar growth phenotype on glucose as substrate compared with the wild-type. In contrast, the mutant shows strongly increased concentrations of nonphosphorylative-Entner-Doudoroff intermediates whereas the hexose and pentose phosphates as well as trehalose are decreased. The results indicate (a) that the nonphosphorylative pathway is able to compensate for the missing semiphosphorylative Entner-Doudoroff branch in glucose catabolism, (b) that in addition to its catabolic function the semiphosphorylative Entner-Doudoroff pathway has an additional although not essential role in providing sugar phosphates for anabolism/gluconeogenesis and (c) that glycerate kinase, with its unusual regulatory properties, seems to play a major role in controlling the flux between the glycolytic nonphosphorylative Entner-Doudoroff and the glycolytic/gluconeogenetic semiphosphorylative Entner-Doudoroff pathway Saccharolobus solfataricus