Cloned (Comment) | Organism |
---|---|
recombinant expression of His-tagged PKM2 in Escherichia coli strain BL21 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(diethylcarbamodithioate) | - |
Homo sapiens | |
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(dimethylcarbamodithioate) | - |
Homo sapiens | |
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(diprop-2-en-1-ylcarbamodithioate) | - |
Homo sapiens | |
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(dipropylcarbamodithioate) | - |
Homo sapiens | |
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) di(1,3-thiazolidine-3-carbodithioate) | - |
Homo sapiens | |
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) dimorpholine-4-carbodithioate | - |
Homo sapiens | |
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) dipyrrolidine-1-carbodithioate | - |
Homo sapiens | |
(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) dithiomorpholine-4-carbodithioate | - |
Homo sapiens | |
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate | - |
Homo sapiens | |
additional information | synthesis and antitumor activity of 2,3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform. In vitro cytotoxicity of target compounds in cancer cell lines, IC50 values, overview | Homo sapiens | |
shikonin | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | Homo sapiens | - |
ATP + pyruvate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14618 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged PKM2 from Escherichia coli strain BL21 by nickel affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-16 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | - |
Homo sapiens | ATP + pyruvate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKM2 | - |
Homo sapiens |
pyruvate kinase M2 isoform | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00096 | - |
pH 7.5, 37°C, recombinant enzyme | Homo sapiens | (1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) di(1,3-thiazolidine-3-carbodithioate) | |
0.00105 | - |
pH 7.5, 37°C, recombinant enzyme | Homo sapiens | (1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) dithiomorpholine-4-carbodithioate | |
0.00233 | - |
pH 7.5, 37°C, recombinant enzyme | Homo sapiens | (1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) dipyrrolidine-1-carbodithioate | |
0.00264 | - |
pH 7.5, 37°C, recombinant enzyme | Homo sapiens | (1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) dimorpholine-4-carbodithioate | |
0.00278 | - |
pH 7.5, 37°C, recombinant enzyme | Homo sapiens | (1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(diethylcarbamodithioate) | |
0.00295 | - |
pH 7.5, 37°C, recombinant enzyme | Homo sapiens | (3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate | |
0.00308 | - |
pH 7.5, 37°C, recombinant enzyme | Homo sapiens | (1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(dipropylcarbamodithioate) | |
0.00882 | - |
pH 7.5, 37°C, recombinant enzyme | Homo sapiens | shikonin | |
0.01 | - |
pH 7.5, 37°C, recombinant enzyme | Homo sapiens | (1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(dimethylcarbamodithioate) | |
0.01 | - |
pH 7.5, 37°C, recombinant enzyme | Homo sapiens | (1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene) bis(diprop-2-en-1-ylcarbamodithioate) |