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Literature summary for 2.7.1.40 extracted from

  • Christofk, H.R.; Vander Heiden, M.G.; Wu, N.; Asara, J.M.; Cantley, L.C.
    Pyruvate kinase M2 is a phosphotyrosine-binding protein (2008), Nature, 452, 181-186.
    View publication on PubMed
Search for more literature for 2.7.1.40

Activating Compound

Activating Compound Comment Organism Structure
fructose 1,6-bisphosphate
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
K433E the point mutant of PKM2 lacks phosphotyrosine peptide -binding ability Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
phosphotyrosine peptide binding of phosphotyrosine peptides to PKM2 results in release of the allosteric activator fructose-1,6-bisphosphate, leading to inhibition of PKM2 enzymatic activity (20–30% inhibition of PKM2 activity in a dose-dependent manner) Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
 SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14618
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
 Homo sapiens ATP + pyruvate
-
 ?
additional information pyruvate kinase M2 is a phosphotyrosine-binding protein Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PKM2
-
 Homo sapiens
pyruvate kinase M2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Homo sapiens