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Literature summary for 2.7.1.40 extracted from

  • Wong, T.S.; Liu, X.B.; Chung-Wai Ho, A.; Po-Wing Yuen, A.; Wai-Man Ng, R.; Ignace Wei, W.
    Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling (2008), Int. J. Cancer, 123, 251-257.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphoenolpyruvate Homo sapiens
-
ATP + pyruvate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
squamous cell carcinoma cell squamous cell carcinoma of tongue Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
Homo sapiens ATP + pyruvate
-
?

Synonyms

Synonyms Comment Organism
PKM2
-
Homo sapiens
pyruvate kinase type M2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ADP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in tongue squamous cell carcinoma cell lines, PKM2 expression is reduced in response to miR-133a and miR-133b precursors transfection down
Homo sapiens PKM2 is overexpressed in tongue squamous cell carcinoma cells and is associated with the downregulation of miR-133a and miR-133b up