Activating Compound | Comment | Organism | Structure |
---|---|---|---|
D-fructose 1,6-bisphosphate | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | activation of the high-affinity IgE receptor FcepsilonRI in RBL-2H3 cells causes the rapid phosphorylation of tyrosine residues in M2PK, associated with a decrease in M2PK enzymatic activity | Rattus norvegicus | |
NaF | non-specific phosphoenolpyruvate kinase inhibitor | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.27 | - |
phosphoenolpyruvate | in the absence of the high-affinity IgE receptor FcepsilonRI | Rattus norvegicus | |
0.59 | - |
phosphoenolpyruvate | in the presence of the high-affinity IgE receptor FcepsilonRI | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RBL-2H3 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | - |
Rattus norvegicus | ATP + pyruvate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
M2-type pyruvate kinase | - |
Rattus norvegicus |
M2PK | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | FcepsilonRI-mediated inhibition of M2-type PK is required for mast cell degranulation | Rattus norvegicus |