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Literature summary for 2.7.1.40 extracted from

  • Ryu, H.; Walker, J.K.; Kim, S.; Koo, N.; Barak, L.S.; Noguchi, T.; Kang, B.Y.; Kim, K.M.
    Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation (2008), Br. J. Pharmacol., 154, 1035-1046.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.40

Activating Compound

Activating Compound Comment Organism Structure
D-fructose 1,6-bisphosphate
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information activation of the high-affinity IgE receptor FcepsilonRI in RBL-2H3 cells causes the rapid phosphorylation of tyrosine residues in M2PK, associated with a decrease in M2PK enzymatic activity Rattus norvegicus
NaF non-specific phosphoenolpyruvate kinase inhibitor Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.27
-
 phosphoenolpyruvate in the absence of the high-affinity IgE receptor FcepsilonRI Rattus norvegicus
0.59
-
 phosphoenolpyruvate in the presence of the high-affinity IgE receptor FcepsilonRI Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RBL-2H3 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
 Rattus norvegicus ATP + pyruvate
-
 ?

Synonyms

Synonyms Comment Organism
M2-type pyruvate kinase
-
 Rattus norvegicus
M2PK
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction FcepsilonRI-mediated inhibition of M2-type PK is required for mast cell degranulation Rattus norvegicus