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Literature summary for 2.7.1.40 extracted from
- Glycolytic inhibition by mutation of pyruvate kinase gene increases oxidative stress and causes apoptosis of a pyruvate kinase deficient cell line (2007), Exp. Hematol., 35, 1190-1200.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Friend erythroleukemic cell line SLC-3 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | contruction of stable transfectants of mouse SLC-3 cells with human pyruvate kinase cDNA. Expression of pyruvate kinase significantly decreases cells at the sub G0/G1 stage in an expression-level dependent manner. Pro-apoptotic genes such as Bad, Bnip3, and Bnip31, are down-regulated in the transfectants. Peroxiredoxin 1 and other antioxidant genes such as Cat, Txnrd1, and Glrx1 are also down-regulated | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
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Release 2023.1 (January 2023)
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