Literature summary for 2.7.1.40 extracted from

Williams, R.; Holyoak, T.; McDonald, G.; Gui, C.; Fenton, A.W.
Differentiating a ligands chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinase (2006), Biochemistry, 45, 5421-5429.

Search for more literature for 2.7.1.40

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapour diffusion method using 60 mM succinate (pH 5.5), 5.8 mM sodium pyruvate, 2.4 mM MnCl2, 450 mM KCl, and a range of 18 to 20% PEG 8000	Oryctolagus cuniculus

Inhibitors

Inhibitors	Comment	Organism	Structure
L-phenylalanine	allosterical inhibitor	Oryctolagus cuniculus
additional information	not inhibited by propionic acid, N-methyl-L-alanine, N-formyl-L-alanine, N-acetyl-L-alanine, 3 phenylpropionic acid, N-methyl-L-phenylalanine, N-formyl-L-phenylalanine, N-acetyl-L-phenylalanine, and N,N-dimethylphenylalanine	Oryctolagus cuniculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required for activity	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	P11974	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Oryctolagus cuniculus	-
muscle	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ADP + phosphoenolpyruvate	-	Oryctolagus cuniculus	ATP + pyruvate	-	?

Synonyms

Synonyms	Comment	Organism
M1-PYK	-	Oryctolagus cuniculus

pH Range

pH Minimum	pH Maximum	Comment	Organism
8	9.5	-	Oryctolagus cuniculus

Cofactor

Cofactor	Comment	Organism	Structure
ADP	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)