Literature summary for 2.7.1.40 extracted from

Feksa, L.R.; Cornelio, A.R.; Dutra-Filho, C.S.; de Souza Wyse, A.T.; Wajner, M.; Wannmacher, C.M.
Characterization of the inhibition of pyruvate kinase caused by phenylalanine and phenylpyruvate in rat brain cortex (2003), Brain Res., 968, 199-205.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Phe	competitive with ADP and phosphoenolpyruvate, Ala prevents inhibition	Rattus norvegicus
phenylpyruvate	competitive with ADP and phosphoenolpyruvate, Ala prevents inhibition	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ADP + phosphoenolpyruvate	Rattus norvegicus	the enzyme catalyzes an important regulatory step in the glycolysis pathway, the main route that provides energy for brain function	ATP + pyruvate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
cerebral cortex	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ADP + phosphoenolpyruvate	-	Rattus norvegicus	ATP + pyruvate	-	?
ADP + phosphoenolpyruvate	the enzyme catalyzes an important regulatory step in the glycolysis pathway, the main route that provides energy for brain function	Rattus norvegicus	ATP + pyruvate	-	?

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Release 2023.1 (January 2023)